上皮-肌上皮唾液腺癌中基质金属蛋白酶-1、-7、-9、-13、Ki-67 和 HER-2 的表达。
Expression of matrix metalloproteinase-1, -7, -9, -13, Ki-67, and HER-2 in epithelial-myoepithelial salivary gland cancer.
机构信息
Department of Otorhinolaryngology - Head and Neck Surgery, Turku University Hospital, University of Turku, Turku, Finland.
出版信息
Head Neck. 2010 Aug;32(8):1019-27. doi: 10.1002/hed.21277.
BACKGROUND
The expression of matrix metalloproteinases (MMPs) in epithelial-myoepithelial salivary gland carcinoma has not been studied previously.
METHODS
Immunohistochemistry for MMP-1, -7, -9, -13, Ki-67, and HER-2, as well as HER-2 gene amplification by silver enhanced in situ hybridization was performed in a series of 12 paraffin-embedded histopathologic samples of patients from Canada and Finland.
RESULTS
A positive MMP-13 (p = .0022), higher MMP-13 (p = .0274), and higher MMP-9 (p = .0274) index (multiplication of staining intensity by percentage of the positive cells) predicted better overall survival. In disease-specific analysis, higher MMP-9 index (p = .0327) predicted better survival. A higher volume corrected index (VCI) of Ki-67 (p = .0339) predicted worse disease-specific survival. In 1 patient, HER-2 oncogene amplification was observed.
CONCLUSION
MMPs and Ki-67 may have prognostic impact in epithelial-myoepithelial carcinoma.
背景
先前尚未研究过上皮-肌上皮涎腺癌中基质金属蛋白酶（MMPs）的表达。
方法
对来自加拿大和芬兰的 12 例石蜡包埋组织病理学样本进行 MMP-1、-7、-9、-13、Ki-67 和 HER-2 的免疫组织化学检测，以及通过银增强原位杂交进行 HER-2 基因扩增。
结果
阳性 MMP-13（p=0.0022）、更高的 MMP-13（p=0.0274）和更高的 MMP-9（p=0.0274）指数（染色强度与阳性细胞百分比的乘积）预测总体生存率更好。在疾病特异性分析中，更高的 MMP-9 指数（p=0.0327）预测生存率更好。Ki-67 的体积校正指数（VCI）更高（p=0.0339）预示着疾病特异性生存率更差。在 1 例患者中观察到 HER-2 致癌基因扩增。
结论
MMPs 和 Ki-67 在上皮-肌上皮癌中可能具有预后影响。
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