分析基质金属蛋白酶-1 基因多态性与良、恶性乳腺肿瘤的表达。
Analysis of matrix metalloproteinase-1 gene polymorphisms and expression in benign and malignant breast tumors.
机构信息
Clinical Breast Care Project, Windber Research Institute, Windber, Pennsylvania, PA 15963, USA.
出版信息
Cancer Invest. 2011 Nov;29(9):599-607. doi: 10.3109/07357907.2011.621915.
Abstract
A guanine insertion polymorphism in matrix metalloproteinase-1 promoter (MMP-1 2G) is linked to early onset and aggressiveness in cancer. We determined the role of MMP-1 2G on MMP-1 expression and breast cancer severity in patients with breast diseases. We observed no significant difference in genotype distribution among different disease groups. However, MMP-1 expression was significantly higher in atypical ductal hyperplasia than in benign breast disease and in invasive breast cancer compared to in situ breast cancer. MMP-1 2G insertion polymorphism in the invasive group also correlated significantly with the expression of MMP-1 and breast cancer prognostic markers HER2 and P53.
摘要
基质金属蛋白酶-1 启动子中的鸟嘌呤插入多态性（MMP-1 2G）与癌症的早期发病和侵袭性相关。我们确定了 MMP-1 2G 在患有乳腺疾病的患者中对 MMP-1 表达和乳腺癌严重程度的作用。我们观察到不同疾病组之间基因型分布没有显著差异。然而，非典型导管增生中 MMP-1 的表达明显高于良性乳腺疾病，并且在浸润性乳腺癌中也高于原位乳腺癌。浸润性组中 MMP-1 2G 插入多态性也与 MMP-1 的表达以及乳腺癌预后标志物 HER2 和 P53 显著相关。
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