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多壁碳纳米管的内体渗漏和核转位：建立细胞摄取模型。

Endosomal leakage and nuclear translocation of multiwalled carbon nanotubes: developing a model for cell uptake.

机构信息

St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

出版信息

Nano Lett. 2009 Dec;9(12):4370-5. doi: 10.1021/nl902647x.

DOI:10.1021/nl902647x
PMID:19902917
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2796686/
Abstract

We report our findings on cellular membrane penetration, endocytosis, endosomal leakage, and nuclear translocation of multiwalled carbon nanotubes (MWCNTs). Our data is consistent with a working model for MWCNTs' cell uptake and cellular translocations.

摘要

我们报告了关于多壁碳纳米管（MWCNTs）的细胞膜穿透、内吞作用、内体漏出和核转位的研究结果。我们的数据与 MWCNTs 细胞摄取和细胞转位的工作模型一致。

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Endosomal leakage and nuclear translocation of multiwalled carbon nanotubes: developing a model for cell uptake.多壁碳纳米管的内体渗漏和核转位：建立细胞摄取模型。
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本文引用的文献

1
Intracellular uptake, trafficking and subcellular distribution of folate conjugated single walled carbon nanotubes within living cells.活细胞内叶酸偶联单壁碳纳米管的细胞内摄取、运输及亚细胞分布
Nanotechnology. 2008 Sep 17;19(37):375103. doi: 10.1088/0957-4484/19/37/375103. Epub 2008 Aug 1.
2
Uptake of noncytotoxic acid-treated single-walled carbon nanotubes into the cytoplasm of human macrophage cells.非细胞毒性酸处理的单壁碳纳米管被人类巨噬细胞摄取进入细胞质。
ACS Nano. 2009 Jun 23;3(6):1485-92. doi: 10.1021/nn900416z.
3
Suppression of human bone morphogenetic protein signaling by carboxylated single-walled carbon nanotubes.羧化单壁碳纳米管抑制人骨形态发生蛋白信号通路。
ACS Nano. 2009 May 26;3(5):1139-44. doi: 10.1021/nn900252j.
4
Reversible accumulation of PEGylated single-walled carbon nanotubes in the mammalian nucleus.聚乙二醇化单壁碳纳米管在哺乳动物细胞核中的可逆积累。
ACS Nano. 2008 Oct 28;2(10):2085-94. doi: 10.1021/nn800461u.
5
Carbon nanotubes as molecular transporters for walled plant cells.碳纳米管作为有细胞壁植物细胞的分子转运体
Nano Lett. 2009 Mar;9(3):1007-10. doi: 10.1021/nl803083u.
6
Noninvasive Raman spectroscopy in living mice for evaluation of tumor targeting with carbon nanotubes.利用无创拉曼光谱技术在活体小鼠中评估碳纳米管的肿瘤靶向性。
Nano Lett. 2008 Sep;8(9):2800-5. doi: 10.1021/nl801362a. Epub 2008 Aug 7.
7
Direct imaging of single-walled carbon nanotubes in cells.细胞中单壁碳纳米管的直接成像。
Nat Nanotechnol. 2007 Nov;2(11):713-7. doi: 10.1038/nnano.2007.347. Epub 2007 Oct 28.
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Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type.功能化碳纳米管的细胞摄取与官能团和细胞类型无关。
Nat Nanotechnol. 2007 Feb;2(2):108-13. doi: 10.1038/nnano.2006.209. Epub 2007 Jan 28.
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Nano Lett. 2008 Aug;8(8):2137-43. doi: 10.1021/nl073300o. Epub 2008 Jul 12.
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Langmuir. 2008 Jun 1;24(13):6409-13. doi: 10.1021/la800951v. Epub 2008 May 30.