Xu Qian, Deng Hao, Li Xiaoting, Quan Zhe-Shan
Key Laboratory of Natural Medicines of the Changbai Mountain, Affiliated Ministry of Education, College of Pharmacy, Yanbian University, Jilin, China.
Department of Pharmaceutical Analysis, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, China.
Front Chem. 2021 Apr 29;9:650569. doi: 10.3389/fchem.2021.650569. eCollection 2021.
Natural products and their derivatives are important sources for drug discovery; however, they usually have poor solubility and low activity and require structural modification. Amino acids are highly soluble in water and have a wide range of activities. The introduction of amino acids into natural products is expected to improve the performance of these products and minimize their adverse effects. Therefore, this review summarizes the application of amino acids in the structural modification of natural products and provides a theoretical basis for the structural modification of natural products in the future. The articles were divided into six types based on the backbone structures of the natural products, and the related applications of amino acids in the structural modification of natural products were discussed in detail.
天然产物及其衍生物是药物发现的重要来源；然而，它们通常具有较差的溶解性和较低的活性，需要进行结构修饰。氨基酸在水中具有高溶解性且具有广泛的活性。将氨基酸引入天然产物有望改善这些产物的性能并使其副作用最小化。因此，本综述总结了氨基酸在天然产物结构修饰中的应用，并为未来天然产物的结构修饰提供理论依据。根据天然产物的骨架结构将文章分为六种类型，并详细讨论了氨基酸在天然产物结构修饰中的相关应用。
