Vick N A, Lin M J, Bigner D D
Acta Neuropathol. 1977 Sep 26;40(1):63-71. doi: 10.1007/BF00688574.
We have studied the sequential morphological events of glial tumorigenesis in neonatal dogs, using high titer subgroup C Bratislava-77 Avian Sarcoma Virus, given as 0.01 ml by intraventricular inoculation. The cells of the subependymal plate are those which seem to form the gliomas; cytoplasmic alterations are evident within 24 h after inoculation and microfoci of gliomas, contiguous with the subependymal plate of the lateral ventricles, are visible within 7 days. Independent tumors are present by the 10th post-inoculation day. These studies support the hypothesis of Globus and Kuhlenbeck, which implicates the cells of the subependymal palte in glial tumorigenesis.
我们使用高滴度C亚群布拉迪斯拉发-77禽肉瘤病毒，通过脑室内接种0.01毫升，研究了新生犬胶质肿瘤发生的连续形态学事件。室管膜下板的细胞似乎是形成胶质瘤的细胞；接种后24小时内细胞质改变明显，接种后7天内可见与侧脑室室管膜下板相邻的胶质瘤微灶。接种后第10天出现独立肿瘤。这些研究支持了Globus和Kuhlenbeck的假说，该假说认为室管膜下板的细胞与胶质肿瘤发生有关。
