State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Protein Cell. 2012 Apr;3(4):262-70. doi: 10.1007/s13238-012-2930-8. Epub 2012 Apr 20.
The process of cortical expansion in the central nervous system is a key step of mammalian brain development to ensure its physiological function. Radial glial (RG) cells are a glial cell type contributing to this progress as intermediate neural progenitor cells responsible for an increase in the number of cortical neurons. In this review, we discuss the current understanding of RG cells during neurogenesis and provide further information on the mechanisms of neurodevelopmental diseases and stem cell-related brain tumorigenesis. Knowledge of neuronal stem cell and relative diseases will bridge benchmark research through translational studies to clinical therapeutic treatments of these diseases.
中枢神经系统的皮层扩张过程是哺乳动物大脑发育的关键步骤，以确保其生理功能。放射状胶质（RG）细胞是一种神经胶质细胞类型，作为中间神经祖细胞对这一进展做出贡献，负责增加皮质神经元的数量。在这篇综述中，我们讨论了 RG 细胞在神经发生过程中的当前认识，并提供了更多关于神经发育性疾病和干细胞相关脑肿瘤发生机制的信息。神经元干细胞及其相关疾病的知识将通过转化研究架起基准研究与这些疾病的临床治疗之间的桥梁。
