National Centre for the Replacement, Refinement and Reduction of Animals in Research, 20 Park Crescent, London W1B1AL, UK.
Toxicology. 2010 Jan 12;267(1-3):14-9. doi: 10.1016/j.tox.2009.11.006. Epub 2009 Nov 10.
Toxicological assessment of pharmaceutical and non-pharmaceutical chemicals is a regulatory requirement to ensure all compounds likely to be exposed to humans or the environment are safe. These studies rely on the use of large numbers of animals and involve a number of assumptions and extrapolations that remain controversial in assuring consumer safety. The UK's National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) has taken a collaborative approach to identify opportunities for implementation of the 3Rs principles (Replacement, Reduction and Refinement) to drive innovation and support animal welfare in toxicity testing. This review highlights the mechanisms by which the NC3Rs is working with the pharmaceutical and chemical industries and regulatory authorities to achieve these goals.
药物和非药物化学制品的毒理学评估是一项监管要求，旨在确保所有可能接触到人类或环境的化合物都是安全的。这些研究依赖于大量动物的使用，并涉及到一些假设和推断，这些在确保消费者安全方面仍然存在争议。英国国家替代、改良和减少研究动物中心（NC3Rs）采取了合作的方法，确定了实施 3Rs 原则（替代、减少和优化）的机会，以推动创新和支持毒理学测试中的动物福利。这篇综述强调了 NC3Rs 与制药和化学工业以及监管机构合作实现这些目标的机制。
