器官芯片：药物开发中工程化人类组织的快速通道。
Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development.
机构信息
Department of Biomedical Engineering, Columbia University in the City of New York, NY 10032, USA.
Department of Biomedical Engineering, Columbia University in the City of New York, NY 10032, USA; Department of Medicine, Columbia University in the City of New York, NY 10032, USA.
出版信息
Cell Stem Cell. 2018 Mar 1;22(3):310-324. doi: 10.1016/j.stem.2018.02.011.
Abstract
Organs-on-a-chip (OOCs) are miniature tissues and organs grown in vitro that enable modeling of human physiology and disease. The technology has emerged from converging advances in tissue engineering, semiconductor fabrication, and human cell sourcing. Encompassing innovations in human stem cell technology, OOCs offer a promising approach to emulate human patho/physiology in vitro, and address limitations of current cell and animal models. Here, we review the design considerations for single and multi-organ OOCs, discuss remaining challenges, and highlight the potential impact of OOCs as a fast-track opportunity for tissue engineering to advance drug development and precision medicine.
摘要
器官芯片（OOCs）是在体外生长的微型组织和器官，可用于模拟人体生理学和疾病。该技术源自组织工程、半导体制造和人类细胞来源方面的融合进展。OOCs 融合了人类干细胞技术的创新，为在体外模拟人类病理/生理学提供了一种很有前途的方法，并解决了当前细胞和动物模型的局限性。在这里，我们回顾了单器官和多器官 OOCs 的设计考虑因素，讨论了仍然存在的挑战，并强调了 OOCs 作为组织工程快速发展药物开发和精准医学的一个机会的潜在影响。
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