Department of Biotechnology, Panjab University, Chandigarh 160014, India.
Mol Cell Biochem. 2010 Feb;335(1-2):255-61. doi: 10.1007/s11010-009-0275-2. Epub 2009 Nov 11.
Present study depicted the role of polymorphisms in estrogen receptor-alpha gene in association with prostate cancer in north Indian population. The study was performed on 157 cases of prostate cancer, 170 cases of BPH, and 170 healthy Indian males diagnosed with prostate cancer and benign prostatic hyperplasia (BPH) and healthy males as controls. Determination of polymorphism in the ER-alpha gene was done by polymerase chain reaction followed by restriction fragment length polymorphism (RFLP) analysis with PvuII and XbaI enzymes. An association was observed between PvuII polymorphism of ER-alpha gene and that of prostate cancer. However, there was no such association with XbaI polymorphism in ER-alpha gene.
本研究描述了雌激素受体-α基因多态性与印度北部人群前列腺癌的关系。该研究在 157 例前列腺癌、170 例良性前列腺增生（BPH）和 170 例经诊断患有前列腺癌和良性前列腺增生（BPH）的印度健康男性以及健康男性对照中进行。通过聚合酶链反应（PCR）和限制性片段长度多态性（RFLP）分析用 PvuII 和 XbaI 酶对 ER-α 基因的多态性进行了测定。观察到 ER-α 基因的 PvuII 多态性与前列腺癌之间存在关联。然而，在 ER-α 基因的 XbaI 多态性中没有这种关联。
