Li Liang, Zhang Xuening, Xia Qinglai, Ma Hui, Chen Li, Hou Wenjing
Department of Radiology, Second Affiliated Hospital of Tianjin Medical University, 23 Pingjiang Road, Hexi District, Tianjin, 300211, China.
Tumour Biol. 2014 May;35(5):4629-35. doi: 10.1007/s13277-014-1606-9. Epub 2014 Jan 12.
Accumulating evidence has suggested that estrogen receptor alpha (ER-α) PvuII polymorphism might be involved in the development of prostate cancer (PCa). However, the results have been inconsistent. We therefore performed a meta-analysis to clarify the associations between ER-α PvuII polymorphism and PCa. A comprehensive search was conducted to identify all case-control studies of ER-α PvuII polymorphism and PCa risk. We used odds ratios (ORs) to assess the strength of the association and 95% confidence intervals (CIs) to give a sense of the precision of the estimate. A total of 14 studies were found to be eligible for meta-analyses of PvuII variant. Results from this study showed that ER-α PvuII polymorphism were significantly associated with PCa risk under all genetic models in overall population (homogeneous codominant model, OR = 1.57, 95% CI = 1.11-2.21, P = 0.010; heterogeneous codominant model, OR = 1.37, 95% CI = 1.06-1.77, P = 0.02; recessive model, OR = 1.27, 95% CI = 1.02-1.57, P = 0.03; dominant model, OR = 1.40, 95% CI = 1.09-1.79, P = 0.009; and allelic model, OR = 1.25, 95% CI = 1.06-1.48, P = 0.010). Further sensitivity analysis confirmed the significant association. In subgroup analyses stratified by PCa type, there was a significant association between PvuII polymorphism and sporadic PCa risk under both Caucasians and Asians. The meta-analysis indicated elected PvuII polymorphism of ER-α was a risk factor for PCa development.
越来越多的证据表明，雌激素受体α（ER-α）PvuII基因多态性可能与前列腺癌（PCa）的发生有关。然而，研究结果并不一致。因此，我们进行了一项荟萃分析，以阐明ER-α PvuII基因多态性与PCa之间的关联。我们进行了全面检索，以确定所有关于ER-α PvuII基因多态性与PCa风险的病例对照研究。我们使用比值比（OR）来评估关联强度，并使用95%置信区间（CI）来表示估计的精确度。共有14项研究符合PvuII变异体荟萃分析的条件。本研究结果表明，在总体人群的所有遗传模型下，ER-α PvuII基因多态性与PCa风险显著相关（共显性模型，OR = 1.57，95% CI = 1.11 - 2.21，P = 0.010；异质性共显性模型，OR = 1.37，95% CI = 1.06 - 1.77，P = 0.02；隐性模型，OR = 1.27，95% CI = 1.02 - 1.57，P = 0.03；显性模型，OR = 1.40，95% CI = 1.09 - 1.79，P = 0.009；等位基因模型，OR = 1.25，95% CI = 1.06 - 1.48，P = 0.010）。进一步的敏感性分析证实了这种显著关联。在按PCa类型分层的亚组分析中，在白种人和亚洲人中，PvuII基因多态性与散发性PCa风险之间均存在显著关联。荟萃分析表明，ER-α的PvuII基因多态性是PCa发生的一个危险因素。
