Premiere Oncology of Arizona, Scottsdale, AZ.
Int J Cancer. 2010 Apr 15;126(8):1777-1787. doi: 10.1002/ijc.25026.
Angiogenesis is essential for the development and growth of tumors. It is a highly regulated process that requires cross-talk between signaling pathways at all stages of blood vessel development and tumor growth, from the recruitment of endothelial cells to vessel maturation. This review summarizes tumor angiogenesis and describes the key signaling pathways governing blood vessel development. The role of angiogenesis in various tumor types is discussed, but the focus is on invasive breast cancer, a disease that will affect approximately 182,000 women in the USA in 2008. Research efforts over the past decade have identified numerous potential, as well as proven therapies with activity in breast cancer. These include chemotherapeutics as well as therapies that inhibit specific angiogenic pathways known as targeted agents. Some of the data from single- and multitargeted antiangiogenic agents are described in this review. "Published 2008 Wiley-Liss, Inc. This article is a US Government work, and, as such, is in the public domain in the United States of America."
血管生成对于肿瘤的发生和生长至关重要。它是一个高度调节的过程，需要在血管生成和肿瘤生长的所有阶段的信号通路之间进行交流，从招募内皮细胞到血管成熟。这篇综述总结了肿瘤血管生成，并描述了控制血管生成的关键信号通路。讨论了血管生成在各种肿瘤类型中的作用，但重点是侵袭性乳腺癌，这种疾病预计将影响 2008 年美国约 182000 名妇女。过去十年的研究工作已经确定了许多潜在的以及已被证明在乳腺癌中具有活性的治疗方法。这些方法包括化疗以及抑制特定血管生成途径的治疗方法，称为靶向药物。本文描述了一些单靶点和多靶点抗血管生成药物的数据。“发表于 2008 年 Wiley-Liss，Inc. 本文是美国政府的一项工作，因此在美国属于公有领域。”
