Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China.
Org Lett. 2009 Dec 17;11(24):5626-8. doi: 10.1021/ol902348t.
An air-stable and structurally tunable chiral (t)Bu-quinolineoxazoline/Pd(II) catalyst system has been developed for the enantioselective oxidative cascade cyclization of a variety of disubstituted olefinic substrates, with the apparent advantages of good yields and excellent enantioselectivities (up to 98% ee) and diastereoselectivities (dr >24:1). A transition-state model has also been proposed to account for the excellent stereocontrol.
已开发出一种空气稳定且结构可调的手性(t)Bu-喹啉噁唑啉/Pd(II)催化剂体系，用于多种取代烯烃底物的对映选择性氧化级联环化反应，具有产率高、对映选择性（高达 98%ee）和非对映选择性（dr>24:1）优异的明显优势。还提出了一个过渡态模型来解释优异的立体控制。
