Pd(II)/(t)Bu-喹啉恶唑啉：一种空气稳定且模块化的手性催化剂体系，用于对映选择性氧化级联环化。
Pd(II)/(t)Bu-quinolineoxazoline: an air-stable and modular chiral catalyst system for enantioselective oxidative cascade cyclization.
机构信息
Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China.
出版信息
Org Lett. 2009 Dec 17;11(24):5626-8. doi: 10.1021/ol902348t.
PMID:19905004
Abstract
An air-stable and structurally tunable chiral (t)Bu-quinolineoxazoline/Pd(II) catalyst system has been developed for the enantioselective oxidative cascade cyclization of a variety of disubstituted olefinic substrates, with the apparent advantages of good yields and excellent enantioselectivities (up to 98% ee) and diastereoselectivities (dr >24:1). A transition-state model has also been proposed to account for the excellent stereocontrol.
摘要
已开发出一种空气稳定且结构可调的手性(t)Bu-喹啉噁唑啉/Pd(II)催化剂体系，用于多种取代烯烃底物的对映选择性氧化级联环化反应，具有产率高、对映选择性（高达 98%ee）和非对映选择性（dr>24:1）优异的明显优势。还提出了一个过渡态模型来解释优异的立体控制。
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