通过 Pd 催化的分子内还原 Heck 反应实现吲哚的对映选择性芳基化去芳构化。
Enantioselective Arylative Dearomatization of Indoles via Pd-Catalyzed Intramolecular Reductive Heck Reactions.
机构信息
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
出版信息
J Am Chem Soc. 2015 Apr 22;137(15):4936-9. doi: 10.1021/jacs.5b01705. Epub 2015 Apr 10.
PMID:25849154
Abstract
A highly enantioselective intramolecular arylative dearomatization of indoles via palladium-catalyzed reductive Heck reactions was developed. The new strategy led to a series of optically active indolines bearing C2-quaternary stereocenters in modest to good yields with excellent enantioselectivities (up to 99% ee).
摘要
发展了一种通过钯催化还原 Heck 反应实现的吲哚的高对映选择性的分子内芳基化去芳构化反应。该新策略以中等至良好的收率和优异的对映选择性（高达 99%ee）得到一系列带有 C2-季碳立体中心的光学活性吲哚啉。
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