用于生物氧化剂的硼酸酯基探针：一类用于氧化还原生物学的新型分子工具。

Boronate-Based Probes for Biological Oxidants: A Novel Class of Molecular Tools for Redox Biology.

作者信息

Sikora Adam, Zielonka Jacek, Dębowska Karolina, Michalski Radosław, Smulik-Izydorczyk Renata, Pięta Jakub, Podsiadły Radosław, Artelska Angelika, Pierzchała Karolina, Kalyanaraman Balaraman

机构信息

Faculty of Chemistry, Institute of Applied Radiation Chemistry, Lodz University of Technology, Lodz, Poland.

Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, WI, United States.

出版信息

Front Chem. 2020 Sep 25;8:580899. doi: 10.3389/fchem.2020.580899. eCollection 2020.

Boronate-based molecular probes are emerging as one of the most effective tools for detection and quantitation of peroxynitrite and hydroperoxides. This review discusses the chemical reactivity of boronate compounds in the context of their use for detection of biological oxidants, and presents examples of the practical use of those probes in selected chemical, enzymatic, and biological systems. The particular reactivity of boronates toward nucleophilic oxidants makes them a distinct class of probes for redox biology studies. We focus on the recent progress in the design and application of boronate-based probes in redox studies and perspectives for further developments.