Bin-Abbas Bassam S, Jabari Moslah A, Issa Sharifah D, Al-Fares Abdullah H, Al-Muhsen Saleh
Department of Pediatrics, Section of Pediatric Endocrinology, Security Forces Hospital, Riyadh, Kingdom of Saudi Arabia.
Saudi Med J. 2011 Jun;32(6):589-92.
To assess the prevalence of vitamin D deficiency in type 1 diabetic (T1DM) children.
In this prospective cross-sectional study, we included 100 Saudi children with T1DM attending the Pediatric Endocrinology and Diabetes Clinics, and 100 healthy controls from the Department of Pediatrics, Security Forces Hospital, Riyadh, Kingdom of Saudi Arabia from June to September 2010. We measured serum 25-hydroxy vitamin D (25OHD), parathyroid hormone, calcium, phosphate, and alkaline phosphatase in these patients, and compared the results with age, gender, and ethnicity-matched control subjects.
The mean levels of 25OHD were significantly lower in the T1DM children compared to the controls (36.7 +/- 14.3 nmol/l versus 44.8 +/- 14.1 nmol/l). In the T1DM children, 64% were mildly, 16% were moderately, and 4% were severely vitamin D deficient as compared with 52% (mildly), 6% (moderately), and 1% (severely) in the control group. Overall, 84% of the T1DM children, and 59% of the healthy children were vitamin D deficient. There was no correlation between glycemic control and 25OHD level.
Prevalence of vitamin D deficiency in diabetic children is relatively high. Therefore, screening for vitamin D deficiency and supplementation of children with low vitamin D levels should be warranted.
评估1型糖尿病（T1DM）儿童维生素D缺乏的患病率。
在这项前瞻性横断面研究中，我们纳入了2010年6月至9月在沙特阿拉伯利雅得安全部队医院儿科内分泌与糖尿病诊所就诊的100名沙特T1DM儿童，以及来自该医院儿科的100名健康对照儿童。我们测量了这些患者的血清25-羟基维生素D（25OHD）、甲状旁腺激素、钙、磷和碱性磷酸酶，并将结果与年龄、性别和种族匹配的对照受试者进行比较。
与对照组相比，T1DM儿童的25OHD平均水平显著降低（36.7±14.3 nmol/l对44.8±14.1 nmol/l）。在T1DM儿童中，64%为轻度维生素D缺乏，16%为中度缺乏，4%为重度缺乏；而对照组中这一比例分别为52%（轻度）、6%（中度）和1%（重度）。总体而言，84%的T1DM儿童和59%的健康儿童存在维生素D缺乏。血糖控制与25OHD水平之间无相关性。
糖尿病儿童维生素D缺乏的患病率相对较高。因此，有必要对维生素D缺乏进行筛查，并对维生素D水平低的儿童进行补充。
