1 Department of Health Sciences, School of Sciences, European University Cyprus, Nicosia, Cyprus.
Department of Health Sciences, School of Sciences, European University Cyprus, Nicosia, Cyprus. HIV Surveillance Department, Hellenic National Public Health Organization, Greece.
Rev Diabet Stud. 2022 Jun 30;18(2):58-67. doi: 10.1900/RDS.2022.18.58.
To evaluate vitamin D ((25OH)D levels) deficiency as a possible cause in the development of DT1 in children and adolescents aged 0-15. We searched PubMed/ Medline, EBSCO, and Cochrane Library to identify potentially eligible articles that examine whether low serum 25(OH)D levels are associated with subsequent development of DT1. All type of research designs, including randomized and non-randomized controlled trials, prospective and retrospective cohort studies, case- control and cross-sectional studies with subjects aged ≤15 years old were consider for inclusion. Seven original studies met the entry criteria. Most of these studies found up to 50% lower levels of vitamin D in children with DT1 compared to control group and a significant positive association between vitamin D levels and of the risk of developing DT1. Results of quality assessment demonstrated moderate to high quality of all the studies included. Vitamin D deficiency may be a possible cause in the development of DT1 in the early years of life and particularly in children with genetic predisposition, whilst the deficiency of vitamin D is a very common occurrence in patients with DT1. Further long-term studies on children are required to determine the role of vitamin D on DT1.
评估维生素 D((25OH)D 水平)缺乏是否是导致 0-15 岁儿童和青少年 1 型糖尿病 (DT1)发展的一个可能原因。我们检索了 PubMed/Medline、EBSCO 和 Cochrane Library，以确定可能符合条件的研究，这些研究旨在探讨低血清 25(OH)D 水平是否与随后发生 DT1 有关。所有类型的研究设计，包括随机和非随机对照试验、前瞻性和回顾性队列研究、病例对照和横断面研究，都考虑了≤15 岁的受试者。符合入选标准的有 7 项原始研究。这些研究中的大多数发现，与对照组相比，DT1 患儿的维生素 D 水平低至 50%，维生素 D 水平与 DT1 发病风险之间存在显著正相关。纳入研究的质量评估结果表明，所有研究的质量均为中等到高水平。维生素 D 缺乏可能是生命早期儿童 1 型糖尿病发病的一个可能原因，特别是在有遗传易感性的儿童中，而维生素 D 缺乏在 DT1 患者中非常常见。需要对儿童进行进一步的长期研究，以确定维生素 D 在 DT1 中的作用。
