Hill's Pet Nutrition, Topeka, KS, USA.
J Anim Physiol Anim Nutr (Berl). 2010 Aug 1;94(4):527-39. doi: 10.1111/j.1439-0396.2009.00940.x. Epub 2009 Nov 11.
The purpose of this study was to determine the iodine (I) requirement in adult cats. Forty-two healthy euthyroid cats (1.6-13.6 years old) were utilized in a randomized complete block design. Cats were fed a dry basal diet (0.23 mg/kg I) for a minimum of 1 month (pre-test) then switched to a different basal diet supplemented with seven levels of KI for 1 year (experimental period). Analysed I concentrations were 0.17, 0.23, 0.47, 1.1, 3.1, 6.9 and 8.8 mg I/kg diet [dry matter (DM) basis] and used to construct a response curve. Response variables included I concentrations in serum, urine and faeces, urinary I:creatinine ratio, I balance, technetium(99m) pertechnetate (Tc(99m)) thyroid:salivary ratio, complete blood count and serum chemistries as well as serum thyroid hormone profiles. No significant changes in food intake, weight gain or clinical signs were noted. Serum I, daily urinary I, daily faecal I and urinary I:creatinine ratio were linear functions of iodine intake. An estimate of the I requirement (i.e. breakpoint) was determined from regression of Tc(99m) thyroid:salivary ratio (scintigraphy) on I intake at 12 months [0.46 mg I/kg diet (DM basis) as well as 9 months I balance (0.44 mg I/kg diet (DM)]. The I requirement estimate determined in our study at 12 months for adult cats (0.46 mg I/kg) was higher than current Association of American Feed Control Officials (AAFCO) recommendations (e.g. 0.35 mg I/kg), but was lower than the 2006 National Research Council (NRC) I recommended allowance (e.g. 1.4 mg I/kg).
本研究旨在确定成年猫的碘（I）需求。42 只健康的甲状腺功能正常的猫（1.6-13.6 岁）采用随机完全区组设计。猫喂食干基础日粮（0.23mg/kg I）至少 1 个月（预测试），然后转换为另一种基础日粮，补充 7 个水平的碘化钾，持续 1 年（实验期）。分析的 I 浓度为 0.17、0.23、0.47、1.1、3.1、6.9 和 8.8mg I/kg 日粮[干物质（DM）基础]，并用于构建响应曲线。响应变量包括血清、尿液和粪便中的 I 浓度、尿 I:肌酐比、I 平衡、锝（99m）高锝酸盐（Tc（99m））甲状腺：唾液比、全血细胞计数和血清化学以及血清甲状腺激素谱。未观察到食物摄入量、体重增加或临床症状的显著变化。血清 I、每日尿 I、每日粪 I 和尿 I:肌酐比与碘摄入量呈线性关系。通过 12 个月时 Tc（99m）甲状腺：唾液比（闪烁扫描）对碘摄入量的回归确定碘需求（即断点）的估计值[0.46mg I/kg 日粮（DM 基础）以及 9 个月的 I 平衡（0.44mg I/kg 日粮（DM）]。本研究中确定的成年猫（12 个月）的碘需求估计值（0.46mg/kg）高于美国饲料控制官员协会（AAFCO）目前的建议值（例如 0.35mg/kg），但低于 2006 年国家研究委员会（NRC）推荐的碘允许量（例如 1.4mg/kg）。
