Chernyak Yu I, Shchukina O G
Angarsk Branch, Institute of Labor Medicine and Human Ecology, Research Center of Medical Ecology, East-Siberian Research Center, Siberian Division of the Russian Academy of Medical Sciences, Russia.
Bull Exp Biol Med. 2009 May;147(5):603-5. doi: 10.1007/s10517-009-0570-7.
Peroxidation processes in male outbred albino rats were studied 1, 2, and 3 months after 90-fold administration of dihydroquercetin in doses of 86, 860, and 3000 mg/kg and flavonoid rutin (reference preparation) in a dose of 86 mg/kg. Dihydroquercetin in a dose of 86 mg/kg was as potent as rutin in modulating the process of peroxidation. Changes in the nonenzymatic antioxidant system and activation of lipid peroxidation were not observed in the delayed period after administration of dihydroquercetin.
研究了雄性远交系白化大鼠在以86、860和3000mg/kg的剂量给予二氢槲皮素90倍剂量以及以86mg/kg的剂量给予类黄酮芦丁（参比制剂）后1、2和3个月时的过氧化过程。86mg/kg剂量的二氢槲皮素在调节过氧化过程方面与芦丁的效力相当。在给予二氢槲皮素后的延迟期内未观察到非酶抗氧化系统的变化和脂质过氧化的激活。
