Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336, Munich, Germany.
Eur Arch Psychiatry Clin Neurosci. 2010 Aug;260(5):427-40. doi: 10.1007/s00406-009-0089-y. Epub 2009 Nov 12.
Deficits in executive functions, e.g. voluntary selection, are considered central to the attention-deficit/hyperactivity disorder (ADHD). The aim of this simultaneous EEG/fMRI study was to examine associated neural correlates in ADHD patients. Patients with ADHD and healthy subjects performed an adapted go/nogo task including a voluntary selection condition allowing participants to freely decide, whether to press the response button. Electrophysiologically, response inhibition and voluntary selection led to fronto-central responses. The fMRI data revealed increased medial/lateral frontal and parietal activity during the voluntary selection task. Frontal brain responses were reduced in ADHD patients compared to controls during free responses, whereas parietal brain functions seemed to be unaffected. These results may indicate that selection processes are related to dysfunctions, predominantly in frontal brain regions in ADHD patients.
执行功能缺陷，例如自愿选择，被认为是注意力缺陷/多动障碍（ADHD）的核心。本同步 EEG/fMRI 研究旨在检查 ADHD 患者的相关神经关联。ADHD 患者和健康受试者进行了改良的 Go/NoGo 任务，包括一个自愿选择条件，允许参与者自由决定是否按下反应按钮。在电生理上，反应抑制和自愿选择导致额中央反应。fMRI 数据显示，在自愿选择任务期间，内侧/外侧额顶叶和顶叶活动增加。与对照组相比，ADHD 患者在自由反应期间额叶大脑反应减少，而顶叶大脑功能似乎不受影响。这些结果可能表明，选择过程与 ADHD 患者的主要在前额叶脑区的功能障碍有关。
