疑似肠易激综合征患者的乳糜泻：病例发现研究。
Celiac disease in patients with presumed irritable bowel syndrome: a case-finding study.
机构信息
Department of Internal Medicine, King Abdullah University Hospital, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.
出版信息
World J Gastroenterol. 2009 Nov 14;15(42):5321-5. doi: 10.3748/wjg.15.5321.
AIM
To estimate the prevalence of celiac disease (CD) in adult patients with presumed irritable bowel syndrome (IBS).
METHODS
Between March 2005 and December 2008, 742 consecutive patients (293 male, median age 43 years, range 18-69 years) fulfilling the Rome II criteria for IBS were prospectively enrolled in the study. IBS was diagnosed via self-completed Rome II modular questionnaires. Anti-tissue transglutaminase (anti-tTG) serology was checked to initially recognize possible CD cases. Patients with a positive test were offered endoscopic duodenal biopsy to confirm the diagnosis of CD.
RESULTS
Thirty two patients (15 male, median age 41 years, range 19-59 years) were found to have organic diseases other than CD. Twenty four patients tested positive for anti-tTG antibodies, and duodenal biopsies confirmed the diagnosis in all of them. Thus, in this patient population with presumed IBS, 3.23% actually had CD.
CONCLUSION
CD is common in patients with presumed IBS. Routine screening for CD in patients with symptoms of IBS is recommended.
目的
评估疑似肠易激综合征（IBS）的成年患者中乳糜泻（CD）的患病率。
方法
2005 年 3 月至 2008 年 12 月，连续前瞻性纳入 742 例符合罗马 II 标准的疑似 IBS 患者（293 例男性，中位年龄 43 岁，范围 18-69 岁）。IBS 通过自我完成的罗马 II 模块问卷进行诊断。检测抗组织转谷氨酰胺酶（anti-tTG）血清学以初步识别可能的 CD 病例。对检测呈阳性的患者进行内镜十二指肠活检以确诊 CD。
结果
32 例患者（15 例男性，中位年龄 41 岁，范围 19-59 岁）被发现患有除 CD 以外的其他器质性疾病。24 例患者的抗 tTG 抗体检测呈阳性，且所有患者的十二指肠活检均确诊为 CD。因此，在这群患有疑似 IBS 的患者中，3.23%实际上患有 CD。
结论
CD 在疑似 IBS 的患者中较为常见。建议对 IBS 症状患者进行 CD 的常规筛查。
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