Correa D S, Tayalia P, Cosendey G, dos Santos D S, Aroca R F, Mazur E, Mendonca C R
Instituto de Física de São Carlos, Universidade de São Paulo, Caixa Postal 369, 13560-970 São Carlos, SP, Brazil.
J Nanosci Nanotechnol. 2009 Oct;9(10):5845-9. doi: 10.1166/jnn.2009.1292.
Two-photon polymerization is a powerful tool for fabricating three-dimensional micro/nano structures for applications ranging from nanophotonics to biology. To tailor such structure for specific purposes it is often important to dope them. In this paper we report on the fabrication of structures, with nanometric surface features (resolution of approximately 700 nm), using two-photon polymerization of an acrylic resin doped with the biocompatible polymer chitosan using a guest-host scheme. The fluorescence background in the Raman spectrum indicates the presence of chitosan throughout the structure. Mechanical characterization reveals that chitosan does not affect the mechanical properties of the host acrylic resin and, consequently, the structures exhibit excellent integrity. The approach presented in this work can be used in the fabrication of micro- and nanostructures containing biopolymers for biomedical applications.
双光子聚合是一种用于制造三维微纳结构的强大工具，其应用范围涵盖从纳米光子学到生物学等多个领域。为了将此类结构定制用于特定目的，对其进行掺杂通常很重要。在本文中，我们报道了使用客体 - 主体方案，通过对掺有生物相容性聚合物壳聚糖的丙烯酸树脂进行双光子聚合，制备具有纳米级表面特征（分辨率约为700 nm）的结构。拉曼光谱中的荧光背景表明壳聚糖存在于整个结构中。力学表征显示壳聚糖不会影响主体丙烯酸树脂的力学性能，因此，这些结构具有出色的完整性。本文提出的方法可用于制造包含生物聚合物的微纳结构，用于生物医学应用。
