Peters J H, Carey L C
Department of Surgery, Grant Medical Center, Columbus, Ohio.
Am J Surg. 1991 Feb;161(2):219-25. doi: 10.1016/0002-9610(91)91134-5.
The performance of pancreaticoduodenectomy by Whipple in 1935 demonstrated that the operation was feasible technically and compatible with reasonable function after recovery. From the mid- to late 1940s until the last 10 years, the procedure was condemned by many because of its associated mortality and morbidity. For reasons that are not clear, the risk of pancreaticoduodenectomy in the last 10 years has fallen to less than 10% and in several centers, less than 5%. Postoperative complications have been reduced and blood transfusions are unnecessary in an increasing number of patients. Furthermore, a normal productive life without the need for medication and with no digestive disorder is expected. Seventy-one percent of patients are able to return to their preoperative occupation.
1935年惠普尔实施的胰十二指肠切除术表明，该手术在技术上是可行的，术后恢复后功能也较为合理。从20世纪40年代中后期到过去十年间，该手术因相关的死亡率和发病率而受到许多人的谴责。出于不明原因，过去十年中胰十二指肠切除术的风险已降至10%以下，在一些中心甚至低于5%。术后并发症有所减少，越来越多的患者无需输血。此外，有望过上正常的、无需药物治疗且无消化紊乱的有成效的生活。71%的患者能够恢复到术前的工作状态。
