碳二亚胺介导的 Lossen 重排反应。
Carbonyldiimidazole-mediated Lossen rearrangement.
机构信息
Chemical Research and Development, Pfizer Global Research and Development, Eastern Point Road, P.O. Box 8013, Groton, Connecticut 06340-8013, USA.
出版信息
Org Lett. 2009 Dec 17;11(24):5622-5. doi: 10.1021/ol9023387.
Carbonyldiimidazole (CDI) was found to mediate the Lossen rearrangement of various hydroxamic acids to isocyanates. This process is experimentally simple and mild, with imidazole and CO(2) being the sole stoichiometric byproduct. Significant for large-scale application, the method avoids the use of hazardous reagents and thus represents a green alternative to standard processing conditions for the Curtius and Hofmann rearrangements.
碳二亚胺（CDI）被发现可以介导各种羟胺酸的Lossen 重排反应，生成异氰酸酯。该过程实验操作简单温和，唯一的化学计量副产物为咪唑和 CO(2)。由于该方法避免了使用危险试剂，因此对于大规模应用具有重要意义，这代表了对 Curtius 和 Hofmann 重排等标准处理条件的绿色替代方案。
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