Department of Molecular Biology and Functional Genomics, Stockholm University, 106 91 Stockholm, Sweden.
Biochem Soc Trans. 2009 Dec;37(Pt 6):1399-403. doi: 10.1042/BST0371399.
A-to-I (adenosine-to-inosine) RNA editing catalysed by the ADARs (adenosine deaminases that act on RNA) is a post-transcriptional event that contributes to protein diversity in metazoans. In mammalian neuronal ion channels, editing alters functionally important amino acids and creates receptor subtypes important for the development of the nervous system. The excitatory AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) and kainate glutamate receptors, as well as the inhibitory GABA(A) [GABA (gamma-aminobutyric acid) type A] receptor, are subject to A-to-I RNA editing. Editing affects several features of the receptors, including kinetics, subunit assembly and cell-surface expression. Here, we discuss the regulation of editing during brain maturation and the impact of RNA editing on the expression of different receptor subtypes.
A 到 I（腺苷到肌苷）RNA 编辑由 ADARs（作用于 RNA 的腺苷脱氨酶）催化，是一种在后转录事件，有助于后生动物的蛋白质多样性。在哺乳动物神经元离子通道中，编辑改变了功能重要的氨基酸，并产生了对神经系统发育很重要的受体亚型。兴奋性 AMPA（alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid）和 kainate 谷氨酸受体，以及抑制性 GABA(A) [GABA (gamma-aminobutyric acid) 类型 A] 受体，都受到 A 到 I RNA 编辑的影响。编辑影响受体的几个特征，包括动力学、亚基组装和细胞表面表达。在这里，我们讨论了大脑成熟过程中编辑的调节以及 RNA 编辑对不同受体亚型表达的影响。
