Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109-5620, USA.
Immunol Rev. 2009 Nov;232(1):240-54. doi: 10.1111/j.1600-065X.2009.00829.x.
Adapter proteins play key roles in intracellular signal transduction through complex formation with catalytically active signaling molecules. In T lymphocytes, the role of several different types of adapter proteins in T-cell antigen receptor signal transduction is well established. An exception to this is the family of T-cell-specific adapter (TSAd) proteins comprising of TSAd, adapter protein of unknown function (ALX), SH2D4A, and SH2D4B. Only recently has the function of these adapters in T-cell signal transduction been explored. Here, we discuss advances in our understanding of the role of this family of adapter proteins in T cells. Their function as regulators of signal transduction in other cell types is also discussed.
衔接蛋白通过与催化活性信号分子形成复合物，在细胞内信号转导中发挥关键作用。在 T 淋巴细胞中，几种不同类型的衔接蛋白在 T 细胞抗原受体信号转导中的作用已得到充分证实。但 T 细胞特异性衔接蛋白（TSAd）家族除外，该家族包括 TSAd、功能未知的衔接蛋白（ALX）、SH2D4A 和 SH2D4B。直到最近，人们才开始研究这些衔接子在 T 细胞信号转导中的作用。在这里，我们讨论了我们对这个衔接蛋白家族在 T 细胞中的作用的理解的进展。还讨论了它们在其他细胞类型中作为信号转导调节剂的功能。
