Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.
Breast Cancer Res. 2009;11(6):213. doi: 10.1186/bcr2416. Epub 2009 Nov 9.
Epithelial-mesenchymal plasticity in breast carcinoma encompasses the phenotypic spectrum whereby epithelial carcinoma cells within a primary tumor acquire mesenchymal features and re-epithelialize to form a cohesive secondary mass at a metastatic site. Such plasticity has implications in progression of breast carcinoma to metastasis, and will likely influence response to therapy. The transcriptional and epigenetic regulation of molecular and cellular processes that underlie breast cancer and result in characteristic changes in cell behavior can be monitored using an increasing array of marker proteins. Amongst these markers exists the potential for emergent prognostic, predictive and therapeutic targeting.
乳腺癌中的上皮-间充质可塑性包含表型谱，其中原发肿瘤中的上皮癌细胞获得间质特征，并重新上皮化，在转移部位形成有凝聚力的次级肿块。这种可塑性对乳腺癌转移的进展有影响，并可能影响治疗反应。可以使用越来越多的标记蛋白来监测乳腺癌中潜在的分子和细胞过程的转录和表观遗传调控，这些过程导致细胞行为的特征性变化。在这些标记物中存在新的预后、预测和治疗靶点的潜力。
