从八角莲果实中分离得到的一种新细胞毒素类黄酮。
A new cytotoxic flavonoid from the fruit of Sinopodophyllum hexandrum.
机构信息
Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, China.
出版信息
Fitoterapia. 2010 Jul;81(5):367-70. doi: 10.1016/j.fitote.2009.11.003. Epub 2009 Nov 10.
Constituents of the fruit of Sinopodophyllum hexandrum (Royle) Ying (Sinopodophylli Fructus) were investigated. A new flavonoid, 8,2'-diprenylquercetin 3-methyl ether along with 9 known compounds were isolated and identified. Among them, the new compound 8,2'-diprenylquercetin 3-methyl ether exhibited cytotoxic activities against MDA-231 and T47D breast cancer cell lines, quercetin, kaempferol and rutin were isolated from Sinopodophylli Fructus for the first time.
对桃儿七（Sinopodophyllum hexandrum （Royle） Ying）果实的成分进行了研究。分离并鉴定了一种新的类黄酮，8,2'-二烯丙基槲皮素 3-甲醚以及 9 种已知化合物。其中，新化合物 8,2'-二烯丙基槲皮素 3-甲醚对 MDA-231 和 T47D 乳腺癌细胞系表现出细胞毒性活性，槲皮素、山奈酚和芦丁首次从桃儿七果实中分离得到。
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