肌醇1,3,4,6-四磷酸在非洲爪蟾卵母细胞中以高效力动员钙。
Inositol 1,3,4,6-tetrakisphosphate mobilizes calcium in Xenopus oocytes with high potency.
作者信息
Ivorra I, Gigg R, Irvine R F, Parker I
机构信息
Department of Psychobiology, University of California, Irvine 92717.
出版信息
Biochem J. 1991 Jan 15;273(Pt 2)(Pt 2):317-21. doi: 10.1042/bj2730317.
Abstract
Injection of Ins(1,3,4,6)P4 into Xenopus oocytes evoked Ca2(+)-dependent membrane currents with a potency 5-10 times less than Ins(1,4,5)P3, whereas Ins(1,3,4)P3 and Ins(1,3,4,5,6)P5 were almost ineffective. Responses to Ins(1,3,4,6)P4 arose through liberation of intracellular Ca2+ and through entry of extracellular Ca2+. These results, together with the observation that Ins(1,3,4,6)P4 facilitated responses to Ins(1,4,5)P3, suggests that both of these compounds may act on the same intracellular receptors.
摘要
将肌醇(1,3,4,6)四磷酸注入非洲爪蟾卵母细胞可诱发依赖钙离子的膜电流，其效力比肌醇(1,4,5)三磷酸低5至10倍，而肌醇(1,3,4)三磷酸和肌醇(1,3,4,5,6)五磷酸几乎无效。对肌醇(1,3,4,6)四磷酸的反应通过细胞内钙离子的释放和细胞外钙离子的内流产生。这些结果，连同观察到肌醇(1,3,4,6)四磷酸促进对肌醇(1,4,5)三磷酸的反应，表明这两种化合物可能作用于相同的细胞内受体。
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