Nebert D W, Nelson D R, Coon M J, Estabrook R W, Feyereisen R, Fujii-Kuriyama Y, Gonzalez F J, Guengerich F P, Gunsalus I C, Johnson E F
Department of Environmental Health, University of Cincinnati Medical Center, OH 45267-0056.
DNA Cell Biol. 1991 Jan-Feb;10(1):1-14. doi: 10.1089/dna.1991.10.1.
We provide here a list of 154 P450 genes and seven putative pseudogenes that have been characterized as of October 20, 1990. These genes have been described in a total of 23 eukaryotes (including nine mammalian and one plant species) and six prokaryotes. Of 27 gene families so far described, 10 exist in all mammals. These 10 families comprise 18 subfamilies, of which 16 and 14 have been mapped in the human and mouse genomes, respectively; to date, each subfamily appears to represent a cluster of tightly linked genes. We propose here a modest revision of the initially proposed (Nebert et al., DNA 6, 1-11, 1987) and updated (Nebert et al., DNA 8, 1-13, 1989) nomenclature system based on evolution of the superfamily. For the gene we recommend that the italicized root symbol CYP for human (Cyp for mouse), representing cytochrome P450, be followed by an Arabic number denoting the family, a letter designating the subfamily (when two or more exist), and an Arabic numeral representing the individual gene within the subfamily. A hyphen should precede the final number in mouse genes. We suggest that the human nomenclature system be used for other species. This system is consistent with our earlier proposed nomenclature for P450 of all eukaryotes and prokaryotes, except that we are discouraging the future use of cumbersome Roman numerals.
我们在此提供一份截至1990年10月20日已被鉴定的154个细胞色素P450基因和7个假定假基因的列表。这些基因已在总共23种真核生物（包括9种哺乳动物和1种植物）和6种原核生物中被描述。在目前已描述的27个基因家族中，有10个存在于所有哺乳动物中。这10个家族包含18个亚家族，其中16个和14个亚家族分别已定位到人类和小鼠基因组中；迄今为止，每个亚家族似乎都代表一组紧密连锁的基因。我们在此基于该超家族的进化，对最初提出的（内伯特等人，《DNA》6，1 - 11，1987）和更新的（内伯特等人，《DNA》8，1 - 13，1989）命名系统进行适度修订。对于基因，我们建议人类基因用斜体的根符号CYP（小鼠基因用Cyp）表示细胞色素P450，后面跟随一个阿拉伯数字表示家族，一个字母表示亚家族（当存在两个或更多亚家族时），以及一个阿拉伯数字表示该亚家族内的单个基因。小鼠基因的最后一个数字前应加一个连字符。我们建议其他物种使用人类命名系统。该系统与我们早期为所有真核生物和原核生物的细胞色素P450提出的命名法一致，只是我们不鼓励未来使用繁琐的罗马数字。
