阿尔茨海默病痴呆精神病的 5-羟色胺能系统基因：荟萃分析。
Serotonergic system genes in psychosis of Alzheimer dementia: meta-analysis.
机构信息
TS Srinivasan Centre for Clinical Neurosciences, The Institute for Neurological Sciences, Taramani, Chennai, India.
出版信息
Am J Geriatr Psychiatry. 2009 Oct;17(10):839-46. doi: 10.1097/JGP.0b013e3181ab8c3f.
OBJECTIVE
The authors attempted to understand the role of two serotonin system genes, HTR2A and SLC6A4, on psychosis associated with Alzheimer dementia (AD).
METHOD
Relevant published studies were assessed, and their data were meta-analyzed to determine pooled odds ratios (ORs) that were assessed for heterogeneity. Additional robustness checks were performed to assess for publication bias and any undue influence from a single study. Finally, the number of studies required to invalidate positive findings was determined.
RESULTS
The C allele of HTR2A emerged as a significant risk factor for psychosis, with an allelic OR of 2.191 that increased to 5.143 for the homozygous CC genotype. The SLC6A4 polymorphism was not reliably associated with either psychosis or delusions.
CONCLUSIONS
The strong and robust positive association that was noted between the C allele of HTR2A and psychosis suggests that the HTR2A T102C polymorphism is a significant risk factor for psychosis of AD.
目的
作者试图了解 5-羟色胺系统基因 HTR2A 和 SLC6A4 对阿尔茨海默病（AD）相关精神病的作用。
方法
评估了相关的已发表研究，并对其数据进行了荟萃分析，以确定评估异质性的合并优势比（OR）。进行了额外的稳健性检查，以评估发表偏倚和单个研究的不当影响。最后，确定了否定阳性发现所需的研究数量。
结果
HTR2A 的 C 等位基因是精神病的显著危险因素，等位基因 OR 为 2.191，杂合 CC 基因型增至 5.143。SLC6A4 多态性与精神病或妄想均无可靠关联。
结论
HTR2A 的 C 等位基因与精神病之间存在强烈而稳健的正相关关系，表明 HTR2A T102C 多态性是 AD 精神病的重要危险因素。
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