The Norfolk & Norwich University Hospital NHS Trust, Colney, Norfolk, NR4 7UY, UK.
Zoonoses Public Health. 2010 Dec;57(7-8):504-9. doi: 10.1111/j.1863-2378.2009.01254.x.
Hepatitis E is a zoonosis that can be acquired by the consumption of contaminated food or water, or via person-to-person spread. However, little is known about the transmission of hepatitis E virus (HEV) in the UK. We investigated the epidemiology of indigenous hepatitis E infection using the PHLS Farm Cohort, a sentinel group with a history of close contact with a range of domestic animals. Ten of the 413 subjects tested were positive for hepatitis E IgG antibodies (2.4%). Seroprevalence peaked in those aged 51 to 60 years (relative risk 3.3, 95% CI: 1.0-10.5). Male participants (relative risk 3.6, 95% CI: 0.6-21.2) and those from farms in the Hereford area of the United Kingdom (relative risk 2.7, 95% CI: 0.8-8.4), an area of mixed livestock farming, were more likely to have serological evidence of previous HEVs exposure, although these findings were not statistically significant. Exposure to pigs, or water from a private supply, was not identified as a significant risk factor. The results of this study suggest that UK farming populations are exposed to HEV, but the predominant route of transmission remains elusive.
戊型肝炎是一种人畜共患病，可以通过食用受污染的食物或水，或通过人与人之间的传播而感染。然而，人们对英国戊型肝炎病毒（HEV）的传播知之甚少。我们利用 PHLS 农场队列（一个与多种家畜密切接触的哨点人群），对本土型戊型肝炎感染的流行病学进行了研究。在 413 名接受检测的受试者中，有 10 人（2.4%）的戊型肝炎 IgG 抗体呈阳性。血清阳性率在 51 至 60 岁年龄组达到峰值（相对风险 3.3，95%可信区间：1.0-10.5）。男性参与者（相对风险 3.6，95%可信区间：0.6-21.2）和来自英国赫里福德地区（混合畜牧区）农场的参与者（相对风险 2.7，95%可信区间：0.8-8.4）更有可能有以前感染过 HEV 的血清学证据，尽管这些发现没有统计学意义。接触猪或私人供水未被确定为重要的危险因素。本研究结果表明，英国的农民群体接触过 HEV，但主要的传播途径仍难以确定。
