Nutrition and Diabetes Department, Durand Hospital Maipu 812 5 M, Buenos Aires, 1006 Argentina.
Clin Biochem. 2010 Mar;43(4-5):435-41. doi: 10.1016/j.clinbiochem.2009.11.003. Epub 2009 Nov 10.
Argentina has experienced marked increases in the prevalence of childhood overweight (OW)/obesity over the last few decades.
We examined (1) the distribution of the mean values of lipids, glucose, and HOMA-IR according to the presence of OW/obesity, age, and sex and (2) the association between metabolic syndrome and OW/obesity, Tanner stage, gender, and HOMA-IR.
Data were collected from 1009 children (508 males) in 10 elementary schools between April and September 2007. BMI, waist circumference, blood pressure, Tanner, lipids, insulin, and glucose were determined. Criteria analogous to ATPIII were used for metabolic syndrome in children.
Over 1009 children (508 males) aged 9.4 + or - 2.0 years were evaluated. One hundred and sixty-five (16.4%) were obese (>95th percentile), and 166 (16.5%) were OW (85-95th). Twenty-five (2.5%) were severely obese (BMI>99th). Most of the children (62%; 613/979) were at Tanner 1. Triglycerides, insulin, and HOMA-IR were higher (p<0.001) and HDL-C lower (p<0.001) in OW/obesity in both age groups and genders. The prevalence of metabolic syndrome was 5.8% overall, 32% in severely obese, 16.4% in OW/obese and 0.4% in normal weight children. Multiple logistic regression showed that BMI (OR 24.48; 95% CI 9.14-65.57), and HOMA-IR (OR 2.09; 95% CI 1.04-4.18) were associated with metabolic syndrome adjusted by gender and Tanner stage. Multiple linear regression also showed that BMI and HOMA-IR were independently associated with the number of metabolic syndrome components (R(2)=0.46).
A substantial number of OW/obese children have the metabolic syndrome. HOMA-IR and BMI were strong predictors of metabolic syndrome in children suggesting that OW/obese school children are at a higher risk for future cardiovascular disease.
在过去几十年中，阿根廷儿童超重（OW）/肥胖的患病率显著增加。
我们检查了（1）根据 OW/肥胖、年龄和性别分布的血脂、葡萄糖和 HOMA-IR 的平均值，以及（2）代谢综合征与 OW/肥胖、Tanner 阶段、性别和 HOMA-IR 之间的关系。
2007 年 4 月至 9 月期间，我们从 10 所小学的 1009 名儿童（508 名男性）中收集数据。测定 BMI、腰围、血压、Tanner 分级、血脂、胰岛素和血糖。儿童代谢综合征采用 ATPIII 类似标准。
共评估了 1009 名（508 名男性）年龄为 9.4±2.0 岁的儿童。165 名（16.4%）肥胖（>95 百分位数），166 名（16.5%）超重（85-95 百分位数）。25 名（2.5%）严重肥胖（BMI>99 百分位数）。大多数儿童（62%；613/979）处于 Tanner1 期。两组和两性中，OW/肥胖者的甘油三酯、胰岛素和 HOMA-IR 较高（p<0.001），HDL-C 较低（p<0.001）。代谢综合征的总体患病率为 5.8%，重度肥胖者为 32%，OW/肥胖者为 16.4%，正常体重者为 0.4%。多元逻辑回归显示，BMI（OR 24.48；95%CI 9.14-65.57）和 HOMA-IR（OR 2.09；95%CI 1.04-4.18）与性别和 Tanner 阶段调整后的代谢综合征相关。多元线性回归也表明，BMI 和 HOMA-IR 与代谢综合征的成分数量独立相关（R（2）=0.46）。
相当数量的 OW/肥胖儿童患有代谢综合征。HOMA-IR 和 BMI 是儿童代谢综合征的强有力预测因子，表明肥胖的学龄儿童未来患心血管疾病的风险更高。
