Department of Medical Biochemistry, Medical Biology and Medical Physics, University of Bari, Bari, Italy.
J Hazard Mater. 2010 Mar 15;175(1-3):1096-100. doi: 10.1016/j.jhazmat.2009.10.054. Epub 2009 Oct 23.
The response of olfactory sensory neurons to TNT and RDX as well as to some volatile organic compounds present in the vapors of antipersonnel landmines has been studied both in the pig and in the rat. GC/MS analyses of different plastic components of six different kinds of landmines were performed in order to identify the components of the "perfume" of mines. Studies on rat olfactory mucosa were carried out with electro-olfactogram and calcium imaging techniques, while changes in the cyclic adenosine monophosphate (cAMP) levels following exposure to odorants and explosives were used as a criterion to evaluate the interaction of TNT and RDX with olfactory receptors in a preparation of isolated pig olfactory cilia. These studies indicate that chemical compounds associated with explosives and explosive devices can activate mammalian olfactory receptors.
已经在猪和大鼠中研究了对 TNT 和 RDX 以及某些存在于杀伤人员地雷蒸气中的挥发性有机化合物的嗅觉感觉神经元的反应。为了识别地雷“香味”的成分，对六种不同地雷的不同塑料成分进行了 GC/MS 分析。使用电嗅图和钙成像技术对大鼠嗅黏膜进行了研究，而暴露于气味剂和爆炸物后环腺苷单磷酸 (cAMP) 水平的变化被用作评估 TNT 和 RDX 与分离的猪嗅纤毛嗅觉受体相互作用的标准。这些研究表明，与爆炸物和爆炸装置相关的化学化合物可以激活哺乳动物嗅觉受体。
