Ursino Mauro, Giannessi Massimo, Frapparelli Marta, Magosso Elisa
Dipartimento di Elettronica, Informatica e Sistemistica, Via Venezia 52, I- 47023 Cesena, Italy.
IEEE Eng Med Biol Mag. 2009 Nov-Dec;28(6):63-71. doi: 10.1109/MEMB.2009.934622.
This work investigates the complex relationships between cerebrovascular dynamics, intracranial pressure (ICP), Cushing response, and short-term systemic regulation via an original mathematical model. The model has been used to analyze the effects of Cushing response on cardiovascular and cerebrovascular quantities during constant ICP elevation and during the occurrence of ICP plateau waves and to investigate the conditions leading to system instability with the formation of slow (0.05-0.1 Hz) arterial pressure waves. The model may be of value to assist clinicians in finding the balance between clinical benefits of Cushing response and its shortcomings.
本研究通过一个原创数学模型，探讨脑血管动力学、颅内压（ICP）、库欣反应以及短期全身调节之间的复杂关系。该模型已被用于分析在颅内压持续升高期间以及颅内压平台波出现时，库欣反应对心血管和脑血管参数的影响，并研究导致系统不稳定并形成缓慢（0.05 - 0.1赫兹）动脉压波的条件。该模型可能有助于临床医生在库欣反应的临床益处与其缺点之间找到平衡。
