Department of Dematology, Assam Medical College and Hospital, Dibrugarh, Assam, India.
Indian J Dermatol Venereol Leprol. 2009 Nov-Dec;75(6):638. doi: 10.4103/0378-6323.57743.
Two multigravidae aged 27 and 29 years, with previous uneventful pregnancies, second being psoriatic, reported at 24 and 28 weeks of pregnancies, with generalized pustular lesions. Laboratory findings, including serum calcium were normal. Ultrasonography showed normal fetal growth. Histopathology confirmed pustular psoriasis. Patients were put on cyclosporine 3 mg/ kg weight/ day after failure of an initial systemic steroid. Blood pressure, pulse, and fetal heart sounds were recorded every 12 hours, and ultrasonography and blood parameters, biweekly. Cyclosporine was tapered and stopped after delivery of two healthy babies at 38 weeks. We conclude that cyclosporine can be an option in the management of pustular psoriasis of pregnancy or psoriasis with pustulation in pregnancy.
两名 27 岁和 29 岁的多产妇，既往妊娠均无异常，第二次妊娠分别为银屑病患者，分别在妊娠 24 周和 28 周时出现全身性脓疱性病变。实验室检查包括血清钙均正常。超声检查显示胎儿生长正常。组织病理学证实为脓疱性银屑病。两名患者在初始全身性类固醇治疗失败后，给予环孢素 3mg/kg 体重/天。每 12 小时记录血压、脉搏和胎儿心音，并每两周进行超声检查和血液参数检查。环孢素在两名健康婴儿分别于 38 周分娩后逐渐减少并停药。我们得出结论，环孢素可作为妊娠脓疱性银屑病或妊娠时出现脓疱性银屑病的治疗选择。
