环孢素治疗疱疹样脓疱病：1例病例报告及文献复习
Cyclosporine in the management of impetigo herpetiformis: a case report and review of the literature.
作者信息
Patsatsi Aikaterini, Theodoridis Theodoros D, Vavilis Dimitrios, Tzevelekis Vasilios, Kyriakou Aikaterini, Kalabalikis Dimitrios, Sotiriadis Dimitrios
机构信息
2nd Department of Dermatology and Venereology, Aristotle University School of Medicine, Papageorgiou Hospital, Thessaloniki, Greece.
出版信息
Case Rep Dermatol. 2013 Mar 23;5(1):99-104. doi: 10.1159/000350564. Print 2013 Jan.
Abstract
A 27-year-old female, gravida 1, para 0, in week 22 of pregnancy, presented with an eruption consisting of annular erythematosquamous plaques with an active polycyclic elevated border comprised of superficial micropustules. Clinical and histological features were typical of impetigo herpetiformis (IH). Systemic steroids resulted in an unstable condition, with no resolution of lesions. Resistance to the above therapeutic scheme served as a stimulus to discuss the use of cyclosporine as a therapeutic option in this condition. Reviewing the limited literature, cyclosporine seems to serve not as a monotherapy in the management of IH but as an additional medication, in order to achieve a stable course of the disease and avoid high doses of systemic steroids.
摘要
一名27岁女性，孕1产0，妊娠22周，出现由环形红斑鳞屑性斑块组成的皮疹，活动性多环状隆起边缘由浅表微脓疱构成。临床和组织学特征符合疱疹样脓疱病（IH）。全身使用类固醇导致病情不稳定，皮损未消退。对上述治疗方案的耐药促使我们讨论将环孢素作为这种情况下的一种治疗选择。回顾有限的文献，环孢素似乎并非作为IH治疗的单一疗法，而是作为一种辅助药物，以实现疾病的稳定病程并避免高剂量的全身类固醇治疗。
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