Trivedi Megha K, Vaughn Alexandra R, Murase Jenny E
Department of Dermatology, University of California, San Francisco, CA, USA.
Medical School, University of Michigan, Ann Arbor, MI, USA.
Int J Womens Health. 2018 Feb 26;10:109-115. doi: 10.2147/IJWH.S125784. eCollection 2018.
Pustular psoriasis of pregnancy (PPP) is a life-threatening condition for both the pregnant mother and fetus, and must be efficiently and accurately diagnosed and treated. This condition has historically been classified as a unique, separate dermatosis of pregnancy. However, current opinion and data suggest that it may be a variant of generalized pustular psoriasis. PPP typically occurs in the third trimester and is characterized by widespread coalescent pustules, desquamation, and systemic symptoms. Clinical features and histopathologic evaluation aid in diagnosis. Treatments during pregnancy include high-dose corticosteroids, cyclosporine, narrow-band ultraviolet B radiation, infliximab, granulocyte and monocyte adsorptive apheresis, and systemic antibiotics. Both the mother and fetus should be closely monitored with appropriate laboratory studies for the duration of the pregnancy and postpartum.
妊娠脓疱型银屑病（PPP）对孕妇和胎儿都是一种危及生命的疾病，必须进行有效且准确的诊断和治疗。这种疾病在历史上一直被归类为一种独特的、独立的妊娠皮肤病。然而，目前的观点和数据表明，它可能是泛发性脓疱型银屑病的一种变体。PPP通常发生在妊娠晚期，其特征为广泛融合的脓疱、脱屑和全身症状。临床特征和组织病理学评估有助于诊断。孕期治疗包括大剂量皮质类固醇、环孢素、窄谱紫外线B照射、英夫利昔单抗、粒细胞和单核细胞吸附性血液成分分离术以及全身性抗生素。在整个孕期和产后，都应对母亲和胎儿进行密切监测，并进行适当的实验室检查。
