Cocchi Monia, Vascellari Marta, Gallina Albino, Agnoletti Fabrizio, Angeletti Roberto, Mutinelli Franco
Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell'Università, Legnaro, Italy.
J Vet Med Sci. 2010 Jan;72(1):103-7. doi: 10.1292/jvms.09-0278. Epub 2009 Nov 13.
Two young dogs belonging to the same kennel placed nearby Treviso (north-eastern Italy) died at the end of 2008 with clinical signs of renal failure. They were subjected to necropsy and were evaluated for histopathological and toxicological changes. Both the animals had same clinical signs and laboratory evidence of uremia. Post mortem investigations revealed severe nephrotoxicosis, associated with uroliths deposition within renal tubules and pelvis. The predominant crystal type was identical to those observed in the kidneys of animals involved in the 2004 and 2007 melamine-associated renal failure epidemic in Asia and US, providing evidence that they share the same causative agent. High doses of melamine were detected in the pet food administered to the dogs, likewise melamine was identified in renal tissue from one dead dog and in urine samples from both the animals. Therefore, a diagnosis of melamine-related nephrotoxicosis was made. To the author's knowledge this is the first report about melamine contamination of pet food from EU.
2008年底，位于特雷维索（意大利东北部）附近同一犬舍的两只幼犬因肾衰竭临床症状死亡。对它们进行了尸检，并评估了组织病理学和毒理学变化。两只动物都有相同的临床症状和尿毒症的实验室证据。死后调查显示严重的肾中毒，伴有肾小管和肾盂内尿石沉积。主要的晶体类型与2004年和2007年亚洲和美国三聚氰胺相关肾衰竭疫情中受影响动物肾脏中观察到的相同，这证明它们有相同的致病因子。在给狗喂食的宠物食品中检测到高剂量的三聚氰胺，同样在一只死狗的肾组织和两只动物的尿液样本中也发现了三聚氰胺。因此，诊断为三聚氰胺相关的肾中毒。据作者所知，这是欧盟宠物食品三聚氰胺污染的第一份报告。
