Jiangsu Key Laboratory of Marine Biotechnology, Huaihai Institute of Technology, Lianyungang 222005, China.
Biol Res. 2009;42(3):365-75. Epub 2009 Nov 2.
To address whether there are differences of variation among repeat motif types and among taxonomic groups, we present here an analysis of variation and correlation of dinucleotide microsatellite repeats in eukaryotic genomes. Ten taxonomic groups were compared, those being primates, mammalia (excluding primates and rodentia), rodentia, birds, fish, amphibians and reptiles, insects, molluscs, plants and fungi, respectively. The data used in the analysis is from the literature published in the Journal of Molecular Ecology Notes. Analysis of variation reveals that there are no significant differences between AC and AG repeat motif types. Moreover, the number of alleles correlates positively with the copy number in both AG and AC repeats. Similar conclusions can be obtained from each taxonomic group. These results strongly suggest that the increase of SSR variation is almost linear with the increase of the copy number of each repeat motif. As well, the results suggest that the variability of SSR in the genomes of low-ranking species seem to be more than that of high-ranking species, excluding primates and fungi.
为了研究重复基序类型和分类群之间是否存在变异差异，我们在此分析了真核生物基因组中二核苷酸微卫星重复的变异和相关性。比较了 10 个分类群，分别是灵长类动物、哺乳动物（不包括灵长类动物和啮齿动物）、啮齿动物、鸟类、鱼类、两栖动物和爬行动物、昆虫、软体动物、植物和真菌。分析中使用的数据来自发表在《分子生态学杂志》上的文献。变异分析表明，AC 和 AG 重复基序类型之间没有显著差异。此外，在 AG 和 AC 重复中，等位基因的数量与拷贝数呈正相关。从每个分类群也可以得到类似的结论。这些结果强烈表明，SSR 变异的增加几乎与每个重复基序的拷贝数的增加呈线性关系。同样，结果表明，除灵长类动物和真菌外，低等物种基因组中的 SSR 变异性似乎高于高等物种。
