Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Cancer Causes Control. 2010 Mar;21(3):479-83. doi: 10.1007/s10552-009-9466-0.
Vitamin D may reduce breast cancer risk through an effect on steroid hormones in cycling women.We conducted a study to determine whether there is an association between circulating 25-hydroxyvitamin D (25(OH)D) and estradiol and progesterone in young women.
Volunteer women aged 18-22 and not using hormonal contraceptives were recruited during summer and winter. They provided demographic and lifestyle information and a blood sample. Women recruited in winter gave a second sample after taking vitamin D supplement for 4 weeks. There were 101 women sampled during the luteal phase (1-14 days prior to the start of the next menstrual period). Generalized estimating equation linear regression models were used to examine the relationship between 25(OH)D and estradiol and progesterone.
Per increase of 10 nmol/l of 25(OH)D, progesterone multiplicatively decreased by a factor of 10% (95% CI 5-14%, p < 0.001) and estradiol decreased by a factor of 3% (95% CI 0-6%, p = 0.04) after adjustment for age, body mass index, ethnicity, season, alcohol use, smoking, and physical activity.
Higher levels of vitamin D may reduce progesterone and estradiol, providing a potential mechanism for reduction in breast cancer risk from increased vitamin D exposure in young women.
维生素 D 可能通过对循环女性类固醇激素的影响来降低乳腺癌风险。我们进行了一项研究，以确定年轻女性循环 25-羟维生素 D（25（OH）D）与雌二醇和孕酮之间是否存在关联。
在夏季和冬季招募年龄在 18-22 岁且未使用激素避孕药的志愿者女性。她们提供了人口统计学和生活方式信息以及血液样本。在冬季招募的女性在服用维生素 D 补充剂 4 周后提供了第二份样本。有 101 名女性在黄体期（下次月经开始前 1-14 天）进行了采样。使用广义估计方程线性回归模型来检查 25（OH）D 与雌二醇和孕酮之间的关系。
在调整年龄、体重指数、种族、季节、酒精使用、吸烟和身体活动后，25（OH）D 每增加 10 nmol/L，孕酮按 10%（95%CI 5-14%，p<0.001）的倍数减少，雌二醇减少 3%（95%CI 0-6%，p=0.04）。
较高水平的维生素 D 可能会降低孕酮和雌二醇，为年轻女性增加维生素 D 暴露降低乳腺癌风险提供了潜在的机制。
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