Pootongkam Suwimon, Asawanonda Pravit
Division of Dermatology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
J Drugs Dermatol. 2009 Nov;8(11 Suppl):s18-24.
Pulsed dye lasers (PDL) are one of the first, and popular, nonablative lasers for the treatment of rhytids and superficial pigmented lesions. Recent addition of a compression handpiece (CHP) allows treatments with minimal adverse effects.
The purpose of this study was to investigate the efficacy and safety of new parameters of 595 nm PDL in the treatment of lentigines and wrinkles in the darker skin phototypes.
Ten female subjects with photodamaged skin were enrolled in this study. One side of the face received three monthly treatments with one pass of PDL with the fluence of 6 J/cm2, 6 msec pulse duration followed by a second pass when lentigines were individually treated with CHP 6 J/cm2, 6 msec with CHP. The untreated side served as control. Digital photography was used for global evaluation while the numbers of lentigines and wrinkles were analyzed by VISIA.
All 10 subjects, aged 39-55 years, completed the study. The mean changes in numbers of lentigines at the twelfth week on the treated side was -6.1 (decrease), while that of the controlled side was +2.8 (increase) (P=0.075, paired t test). There was also a statistically significant difference in the degree of improvement of lentigines by global assessment (P=0.008, Wilcoxon signed rank test). No statistically significant difference in the degree of improvement of wrinkles analyzed by VISIA (P=0.490) and global assessment (P=0.157, Wilcoxon signed rank test) was observed. Hyperpigmentation was seen in two subjects.
The parameters of 595 nm PDL used in this study are effective and safe in the treatment of facial lentigines. There was no significant improvement in wrinkles in this study. A study limitation may be the relatively small sample size.
脉冲染料激光（PDL）是最早且常用的非剥脱性激光之一，用于治疗皱纹和浅表色素沉着性病变。最近添加的压缩手持件（CHP）使治疗的不良反应最小化。
本研究旨在探讨595nm脉冲染料激光新参数治疗深色皮肤光型的雀斑和皱纹的疗效和安全性。
10名有光损伤皮肤的女性受试者参与本研究。面部一侧每月接受三次治疗，单次脉冲染料激光治疗，能量密度为6J/cm²，脉冲持续时间为6毫秒，随后当用CHP单独治疗雀斑时进行第二次治疗，CHP能量密度为6J/cm²，脉冲持续时间为6毫秒。未治疗的一侧作为对照。使用数码摄影进行整体评估，同时通过VISIA分析雀斑和皱纹的数量。
所有10名年龄在39 - 55岁的受试者完成了研究。治疗侧在第12周时雀斑数量的平均变化为-6.1（减少），而对照侧为+2.8（增加）（P = 0.075，配对t检验）。通过整体评估，雀斑改善程度也有统计学显著差异（P = 0.008，Wilcoxon符号秩检验）。通过VISIA分析（P = 0.490）和整体评估（P = 0.157，Wilcoxon符号秩检验）观察到皱纹改善程度无统计学显著差异。两名受试者出现色素沉着。
本研究中使用的595nm脉冲染料激光参数在治疗面部雀斑方面有效且安全。本研究中皱纹无明显改善。研究的局限性可能是样本量相对较小。
