Garden Jerome M, Bakus Abnoeal D, Domankevitz Yacov
Department of Dermatology, Northwestern University, Chicago, Illinois, USA.
Dermatol Surg. 2008 Feb;34(2):179-83. doi: 10.1111/j.1524-4725.2007.34035.x. Epub 2007 Dec 17.
The 595-nm pulsed dye laser has been the standard of care for many vascular lesions and has rarely been used in the treatment of epidermal pigmented lesions.
The objective was to investigate the effectiveness and safety of a compression technique for the treatment of epidermal pigmented lesion using a modified 595-nm pulsed dye laser with no epidermal cooling.
Twelve subjects (mean age 58 years) underwent treatments using a modified 595-nm dye laser with a compression handpiece and no epidermal cooling. Treatments were performed with radiant exposures of 7 to 12 J/cm(2), 7-mm spot size, and 1.5-ms pulse duration. Each subject received one to four treatments, 4 to 6 weeks apart. Follow-up evaluations were held before each treatment and 4 months after last treatment.
Clearance of 75% to 100% was obtained in 43, 59, 76, and 79% of the lesions treated after one, two, three, and four treatments respectively. The fourth treatment was evaluated 4 months posttreatment. Side effects included immediate erythema and edema and rare cases of transient hyperpigmentation and atrophy. No purpura and long-lasting side effects were observed.
The compression technique with a modified 595-nm pulsed dye laser system is effective and safe for the treatment of epidermal pigmented lesions.
595纳米脉冲染料激光一直是许多血管性病变的治疗标准，很少用于治疗表皮色素沉着病变。
本研究旨在探讨一种加压技术的有效性和安全性，该技术使用改良的595纳米脉冲染料激光且不进行表皮冷却来治疗表皮色素沉着病变。
12名受试者（平均年龄58岁）接受了使用改良的595纳米染料激光及加压手持件且不进行表皮冷却的治疗。治疗时的辐射剂量为7至12焦耳/平方厘米，光斑大小为7毫米，脉冲持续时间为1.5毫秒。每位受试者接受1至4次治疗，每次治疗间隔4至6周。在每次治疗前及最后一次治疗后4个月进行随访评估。
分别在一次、两次、三次和四次治疗后，75%至100%的病变清除率分别为43%、59%、76%和79%。在第四次治疗后4个月进行评估。副作用包括即刻红斑和水肿，以及罕见的短暂性色素沉着和萎缩病例。未观察到紫癜和长期副作用。
改良的595纳米脉冲染料激光系统的加压技术治疗表皮色素沉着病变有效且安全。
