School of Chemistry, Center for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland.
J Am Chem Soc. 2009 Dec 9;131(48):17542-3. doi: 10.1021/ja908006r.
The synthesis and photophysical evaluation of a new supramolecular lanthanide complex is described which was developed as a luminescent contrast agent for bone structure analysis. We show that the Eu(III) emission of this complex is not pH dependent within the physiological pH range and its steady state emission is not significantly modulated by a series of group I and II as well as D-metal ions and that this agent can be successfully employed to image mechanically formed cracks (scratches) in bone samples after 4 or 24 h, using confocal laser-scanning microscopy.
描述了一种新的超分子镧系配合物的合成和光物理评价，该配合物被开发为用于骨结构分析的发光对比剂。我们表明，该配合物的 Eu(III)发射在生理 pH 范围内不受 pH 值影响，其稳态发射也不会被一系列 I 族和 II 族以及 D 族金属离子显著调制，并且该试剂可以成功地用于在使用共聚焦激光扫描显微镜 4 或 24 小时后对骨样品中的机械形成的裂缝（划痕）进行成像。
