Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Cell Host Microbe. 2009 Nov 19;6(5):403-8. doi: 10.1016/j.chom.2009.10.010.
HIV-1 disrupts the homeostatic equilibrium between the host and coinfecting microbes, facilitating reactivation of persistent viruses and invasion by new viruses. These viruses usually accelerate HIV disease but occasionally create conditions detrimental for HIV-1. Understanding these phenomena may lead to anti-HIV-1 strategies that specifically target interactions between HIV-1 and coinfecting viruses.
HIV-1 打破了宿主与共感染微生物之间的动态平衡，促进了潜伏病毒的重新激活和新病毒的入侵。这些病毒通常会加速 HIV 疾病的进展，但偶尔也会造成不利于 HIV-1 的条件。了解这些现象可能会导致针对 HIV-1 与共感染病毒之间相互作用的抗 HIV-1 策略。
