Department of Biophysics, Medical (TIP) Faculty, Süleyman Demirel University, Morfoloji Binasi, TR-32260 Isparta, Turkey.
Biomed Pharmacother. 2009 Dec;63(10):717-22. doi: 10.1016/j.biopha.2009.04.042. Epub 2009 Oct 14.
Recent studies have shown that hormone replacement therapy (HRT) can exert regulatory affects on lipid and glucose homeostasis. It has been demonstrated that hyperglycemia also involving the formation of lipid peroxides, exert several biological effects that may contribute to the onset and progression of thyroid and kidney abnormalities of postmenopausal women Type 2 diabetes. Therefore, the aim of our study was to evaluate the effect of HRT, vitamin C and E (VCE) treatments on some plasma biochemical and hematological parameters and plasma thyroid hormone levels in postmenopausal women with or without diabetes. Oral HRT and VCE supplementation were compared with no HRT treatment in 40 non-diabetic postmenopausal women and 40 postmenopausal women with Type 2 diabetes mellitus, in a 6-week randomized prospective study. In the 20 women with diabetes who received oral HRT and the 20 women with diabetes who received HRT plus VCE, there was a significant fall in urea, uric acid, creatinine, total bilirubin, conjugated bilirubin, AST, ALT, LDH values. There was no significant change in red blood cell counts, total protein, albumin, sodium, potassium, hematocrit, hemoglobin and free thyrotoxine and triiodothyronine values in postmenopausal women with diabetes or treated with oral HRT and VCE. In conclusion, daily VCE and HRT administrations seem to produce significant improvement on biochemical parameters in the blood of postmenopausal women with Type 2 diabetes. The HRT and VCE supplementations may strengthen the antioxidant defense system and they may play a role in preventing kidney and liver diseases of postmenopausal women with Type 2 diabetes.
最近的研究表明，激素替代疗法（HRT）可以对脂质和葡萄糖稳态发挥调节作用。已经证明，高血糖也涉及脂质过氧化的形成，发挥几种生物学效应，可能有助于绝经后妇女 2 型糖尿病甲状腺和肾脏异常的发生和进展。因此，我们的研究目的是评估 HRT、维生素 C 和 E（VCE）治疗对绝经后妇女和绝经后妇女的一些血浆生化和血液参数以及血浆甲状腺激素水平的影响。在 40 名非糖尿病绝经后妇女和 40 名 2 型糖尿病绝经后妇女中进行了为期 6 周的随机前瞻性研究，比较了口服 HRT 和 VCE 补充治疗与无 HRT 治疗的效果。在接受口服 HRT 的 20 名糖尿病妇女和接受 HRT 加 VCE 的 20 名糖尿病妇女中，尿素、尿酸、肌酐、总胆红素、结合胆红素、AST、ALT、LDH 值显着下降。糖尿病妇女或接受口服 HRT 和 VCE 治疗的妇女的红细胞计数、总蛋白、白蛋白、钠、钾、血细胞比容、血红蛋白和游离甲状腺素和三碘甲状腺原氨酸值无显着变化。结论：每日 VCE 和 HRT 给药似乎对 2 型糖尿病绝经后妇女的血液生化参数有显着改善。HRT 和 VCE 补充可能增强抗氧化防御系统，它们可能在预防 2 型糖尿病绝经后妇女的肾脏和肝脏疾病方面发挥作用。
