Department of Internal Medicine, University of Pisa, Pisa, Italy.
Biomed Pharmacother. 2009 Dec;63(10):742-53. doi: 10.1016/j.biopha.2009.08.003. Epub 2009 Oct 13.
Thyroid dysfunction, however mild, can significantly affect the cardiovascular (CV) system. The effects of thyroid hormones may be viewed as genomic and non-genomic, with the former occurring over a longer time scale and both affecting structural and functional proteins in CV tissue. As the interplay between thyroid function and the CV system becomes elucidated, particularly in the context of a system biology approach, the heart failure phenotype is better understood. Symptomatology is related to disturbance in inotropic and chronotropic function. Moreover, biochemical changes reflected by thyroid function testing with the non-thyroidal illness syndrome can prognosticate and guide therapy in heart failure. In addition, empiric treatment with thyroid hormone analogues or T3 represent emergent and highly controversial interventions.
甲状腺功能障碍，无论其程度如何轻微，都可能对心血管系统产生重大影响。甲状腺激素的作用可以被视为基因组和非基因组的，前者发生在更长的时间尺度上，两者都会影响心血管组织中的结构性和功能性蛋白质。随着甲状腺功能与心血管系统之间的相互作用被阐明，特别是在系统生物学方法的背景下，心力衰竭表型得到了更好的理解。症状与变力和变时功能障碍有关。此外，非甲状腺疾病综合征的甲状腺功能检查所反映的生化变化可以预测心力衰竭的预后并指导治疗。此外，甲状腺激素类似物或 T3 的经验性治疗代表了紧急和极具争议的干预措施。
