Faculty of Biology and Biotechnology and Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Al-Farabi Av., 71, Almaty 050040, Kazakhstan.
Institute of Genetic and Physiology, Al-Farabi Av., 93, Almaty 050040, Kazakhstan.
Molecules. 2022 Nov 2;27(21):7487. doi: 10.3390/molecules27217487.
In terms of prevalence, thyroid pathology, associated both with a violation of the gland function and changes in its structure, occupies one of the main places in clinical endocrinology. The problem of developing low-toxic and highly effective herbal preparations for the correction of thyroid hypofunction and its complications is urgent. Salidroside is a glucoside of tyrosol, found mostly in the roots of spp., and has various positive biological activities. The purpose of this study was to study the antihypothyroid potential of salidrosid-containing extract from roots, which was evaluated on a mercazolyl hypothyroidism model. We showed that extract containing salidroside is a safe and effective means of hypothyroidism correction, significantly reducing ( ≤ 0.001) the level of thyroid-stimulating hormone and increasing the level of thyroid hormones. The combined use of extract with potassium iodide enhances the therapeutic effect of the extract by 1.3-times.
在患病率方面，甲状腺病理学与腺体功能障碍和结构变化有关，在临床内分泌学中占据主要地位之一。开发用于纠正甲状腺功能减退及其并发症的低毒、高效草药制剂是当务之急。红景天苷是酪醇的糖苷，主要存在于 spp. 的根中，具有多种积极的生物学活性。本研究旨在研究含红景天苷的 根提取物的抗甲状腺功能减退作用，该提取物在巯基咪唑致甲状腺功能减退模型中进行了评估。我们表明，含红景天苷的提取物是一种安全有效的甲状腺功能减退症纠正手段，可显著降低（≤0.001）促甲状腺激素水平并提高甲状腺激素水平。红景天苷提取物与碘化钾联合使用可使提取物的治疗效果提高 1.3 倍。
