伴有前列腺腺癌的勒-特雷拉征：一例报告
Sign of Leser-Trélat with an adenocarcinoma of the prostate: a case report.
作者信息
Kluger Nicolas, Guillot Bernard
机构信息
Service de Dermatologie, Universite Montpellier I, Hopital Saint-Eloi CHU de Montpellier, 80, Avenue Augustin Fliche, FR-34295 Montpellier Cedex 5, France.
出版信息
Cases J. 2009 Aug 26;2:8868. doi: 10.4076/1757-1626-2-8868.
INTRODUCTION
The sign of Leser-Trélat is defined by the sudden appearance and rapid increase in number and size of seborrheic keratoses, preceding or revealing a malignancy. Even though this sign remains controversial, it has been described during a wide range of malignancies, including mainly adenocarcinoma of the gastro-intestinal tract or the breast.
CASE PRESENTATION
We report the case of a 68-year-old man who experienced sudden increased in number of seborrheic keratoses within two years prior to a diagnosis of adenocarcinoma of the prostate. After prostatectomy, pigmented lesions stopped their brutal increase but did not regress.
CONCLUSION
This is the second case of adenocarcinoma of the prostate associated with the sign of Leser-Trélat. This report acts as a reminder that in case of Leser-Trélat sign, a complete physical examination is mandatory followed by specific complementary exams.
引言
Leser-Trélat征的定义为脂溢性角化病突然出现，数量和大小迅速增加，发生在恶性肿瘤之前或提示恶性肿瘤。尽管该体征仍存在争议，但已在多种恶性肿瘤中被描述，主要包括胃肠道或乳腺的腺癌。
病例报告
我们报告一例68岁男性，在诊断为前列腺腺癌前两年内，脂溢性角化病数量突然增加。前列腺切除术后，色素沉着性病变停止了急剧增长，但并未消退。
结论
这是第二例与Leser-Trélat征相关的前列腺腺癌病例。本报告提醒，出现Leser-Trélat征时，必须进行全面体格检查，随后进行特定的补充检查。
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