Swaroop Rohina, Zabaneh Raja, Parimoo Nakul
Northwest Louisiana Nephrology 1800 Buckner Street, Suite C-120, Shreveport, LA 71101 USA.
Cases J. 2009 Aug 12;2:8138. doi: 10.4076/1757-1626-2-8138.
Cardiovascular benefits and improved survival have resulted in statins becoming the most prescribed drugs in USA. There is a small but significant risk of developing statin induced rhabdomyolysis especially in combination with other lipid lowering medications for example fibrates like Gemfibrozil.
We describe a case of an 82 year old male patient who developed rhabdomyolysis while taking a combination of Simvastatin and Gemfibrozil and was successfully managed with plasmapheresis.
There are only a few cases of rhabdomyolysis treated with plasmapheresis reported in literature. Most of the case reports of using this technique in rhabdomyolysis have been from Asia, Australia and Europe. We suggest that plasmapheresis may be considered as an option in severe life threatening rhabdomyolysis.
他汀类药物带来的心血管益处及生存率的提高，使其成为美国处方量最大的药物。他汀类药物诱发横纹肌溶解症的风险虽小但显著，尤其是与其他降脂药物合用时，如吉非贝齐等贝特类药物。
我们描述了一例82岁男性患者，在服用辛伐他汀和吉非贝齐联合用药时发生横纹肌溶解症，并通过血浆置换成功治疗。
文献中报道的采用血浆置换治疗横纹肌溶解症的病例较少。大多数关于在横纹肌溶解症中使用该技术的病例报告来自亚洲、澳大利亚和欧洲。我们建议，对于严重危及生命的横纹肌溶解症，可考虑将血浆置换作为一种治疗选择。
