横纹肌溶解症患者的血浆置换：一例报告
Plasmapheresis in a patient with rhabdomyolysis: a case report.
作者信息
Swaroop Rohina, Zabaneh Raja, Parimoo Nakul
机构信息
Northwest Louisiana Nephrology 1800 Buckner Street, Suite C-120, Shreveport, LA 71101 USA.
出版信息
Cases J. 2009 Aug 12;2:8138. doi: 10.4076/1757-1626-2-8138.
Abstract
INTRODUCTION
Cardiovascular benefits and improved survival have resulted in statins becoming the most prescribed drugs in USA. There is a small but significant risk of developing statin induced rhabdomyolysis especially in combination with other lipid lowering medications for example fibrates like Gemfibrozil.
CASE PRESENTATION
We describe a case of an 82 year old male patient who developed rhabdomyolysis while taking a combination of Simvastatin and Gemfibrozil and was successfully managed with plasmapheresis.
CONCLUSION
There are only a few cases of rhabdomyolysis treated with plasmapheresis reported in literature. Most of the case reports of using this technique in rhabdomyolysis have been from Asia, Australia and Europe. We suggest that plasmapheresis may be considered as an option in severe life threatening rhabdomyolysis.
摘要
引言
他汀类药物带来的心血管益处及生存率的提高，使其成为美国处方量最大的药物。他汀类药物诱发横纹肌溶解症的风险虽小但显著，尤其是与其他降脂药物合用时，如吉非贝齐等贝特类药物。
病例介绍
我们描述了一例82岁男性患者，在服用辛伐他汀和吉非贝齐联合用药时发生横纹肌溶解症，并通过血浆置换成功治疗。
结论
文献中报道的采用血浆置换治疗横纹肌溶解症的病例较少。大多数关于在横纹肌溶解症中使用该技术的病例报告来自亚洲、澳大利亚和欧洲。我们建议，对于严重危及生命的横纹肌溶解症，可考虑将血浆置换作为一种治疗选择。
相似文献
1
Plasmapheresis in a patient with rhabdomyolysis: a case report.横纹肌溶解症患者的血浆置换：一例报告
Cases J. 2009 Aug 12;2:8138. doi: 10.4076/1757-1626-2-8138.
2
Delayed presentation of severe rhabdomyolysis leading to acute kidney injury following atorvastatin-gemfibrozil combination therapy: a case report.阿托伐他汀与吉非贝齐联合治疗后出现严重横纹肌溶解症并导致急性肾损伤的延迟表现：一例病例报告
J Med Case Rep. 2018 May 22;12(1):143. doi: 10.1186/s13256-018-1685-0.
3
[Rhabdomyolysis secondary to simvastatin and phenofibrate].辛伐他汀和非诺贝特继发的横纹肌溶解症
Semergen. 2014 May-Jun;40(4):e91-4. doi: 10.1016/j.semerg.2014.01.007. Epub 2014 Apr 24.
4
Rhabdomyolysis with HMG-CoA reductase inhibitors and gemfibrozil combination therapy.横纹肌溶解症与HMG-CoA还原酶抑制剂和吉非贝齐联合治疗。
Pharmacoepidemiol Drug Saf. 2004 Jul;13(7):417-26. doi: 10.1002/pds.977.
5
Reporting rate of rhabdomyolysis with fenofibrate + statin versus gemfibrozil + any statin.非诺贝特与他汀类药物联用对比吉非贝齐与任何他汀类药物联用导致横纹肌溶解的报告率。
Am J Cardiol. 2005 Jan 1;95(1):120-2. doi: 10.1016/j.amjcard.2004.08.076.
6
Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs.接受降脂药物治疗的患者中住院横纹肌溶解症的发病率。
JAMA. 2004 Dec 1;292(21):2585-90. doi: 10.1001/jama.292.21.2585. Epub 2004 Nov 22.
7
Recovery time in a case of gemfibrozil and simvastatin-associated rhabdomyolysis.吉非贝齐与辛伐他汀相关横纹肌溶解症一例的恢复时间。
South Med J. 2009 Aug;102(8):858-60. doi: 10.1097/SMJ.0b013e3181ad6078.
8
Fatal rhabdomyolysis caused by lipid-lowering therapy.降脂治疗导致的致命性横纹肌溶解症。
South Med J. 2001 Oct;94(10):1023-6.
9
Statin-Associated Necrotizing Myopathy: A Feared Complication.他汀类药物相关性坏死性肌病：一种可怕的并发症。
Cureus. 2020 Nov 24;12(11):e11689. doi: 10.7759/cureus.11689.
10
[Rhabdomyolysis and anuric kidney failure induced by the treatment with a gemfibrozil-cerivastatin combination].吉非贝齐-西立伐他汀联合治疗引起的横纹肌溶解和无尿性肾衰竭
Nefrologia. 2001 Sep-Oct;21(5):497-500.
引用本文的文献
1
Dual concomitant CytoSorb hemoadsorption therapy in severe rhabdomyolysis: A novel approach to myoglobin clearance and organ preservation.双重同步CytoSorb血液吸附疗法治疗严重横纹肌溶解症：一种清除肌红蛋白和保护器官的新方法。
Int J Artif Organs. 2025 Jun;48(6):429-433. doi: 10.1177/03913988251339080. Epub 2025 May 16.
2
Continuous venovenous hemodiafiltration versus standard medical therapy for the prevention of rhabdomyolysis-induced acute kidney injury: a retrospective cohort study.连续性静脉-静脉血液透析滤过与标准药物治疗预防横纹肌溶解症致急性肾损伤的回顾性队列研究。
BMC Nephrol. 2023 Jul 19;24(1):215. doi: 10.1186/s12882-023-03242-x.
3
Avian Toxins and Poisoning Mechanisms.禽类毒素与中毒机制。
J Med Toxicol. 2022 Oct;18(4):321-333. doi: 10.1007/s13181-022-00891-6. Epub 2022 Apr 26.
4
Rhabdomyolysis: an American Association for the Surgery of Trauma Critical Care Committee Clinical Consensus Document.横纹肌溶解症：美国创伤外科协会重症监护委员会临床共识文件
Trauma Surg Acute Care Open. 2022 Jan 27;7(1):e000836. doi: 10.1136/tsaco-2021-000836. eCollection 2022.
5
Blood purification with a cytokine adsorber for the elimination of myoglobin in critically ill patients with severe rhabdomyolysis.血液净化用细胞因子吸附剂清除危重症横纹肌溶解症患者肌红蛋白。
Crit Care. 2021 Jan 28;25(1):41. doi: 10.1186/s13054-021-03468-x.
6
A "crush" course on rhabdomyolysis: risk stratification and clinical management update for the perioperative clinician.横纹肌溶解症速成课：围手术期临床医生的风险分层和临床管理更新。
J Anesth. 2020 Aug;34(4):585-598. doi: 10.1007/s00540-020-02792-w. Epub 2020 May 18.
7
Acute kidney injury due to rhabdomyolysis and renal replacement therapy: a critical review.横纹肌溶解所致急性肾损伤及肾脏替代治疗：一项批判性综述
Crit Care. 2014 May 28;18(3):224. doi: 10.1186/cc13897.
本文引用的文献
1
Bench-to-bedside review: Rhabdomyolysis -- an overview for clinicians.从 bench 到床边综述：横纹肌溶解症——临床医生概述
Crit Care. 2005 Apr;9(2):158-69. doi: 10.1186/cc2978. Epub 2004 Oct 20.
2
Extracorporeal therapies in acute rhabdomyolysis and myoglobin clearance.急性横纹肌溶解症的体外治疗与肌红蛋白清除
Crit Care. 2005 Apr;9(2):141-2. doi: 10.1186/cc3055. Epub 2005 Feb 8.
3
Treatment of fibrate-induced rhabdomyolysis with plasma exchange in ESRD.
Am J Kidney Dis. 2005 Mar;45(3):e57-60. doi: 10.1053/j.ajkd.2004.12.003.
4
Statin-associated myopathy.他汀类药物相关肌病
JAMA. 2003 Apr 2;289(13):1681-90. doi: 10.1001/jama.289.13.1681.
5
Safety considerations for statins.他汀类药物的安全性考量
Curr Opin Lipidol. 2002 Dec;13(6):637-44. doi: 10.1097/00041433-200212000-00007.
6
Statin-fibrate combination therapy.他汀类药物与贝特类药物联合治疗。
Ann Pharmacother. 2001 Jul-Aug;35(7-8):908-17. doi: 10.1345/aph.10315.
7
Successful treatment of fulminating complications associated with extensive rhabdomyolysis by plasma exchange.通过血浆置换成功治疗与广泛横纹肌溶解相关的暴发性并发症。
Artif Organs. 1981 Nov;5(4):372-8. doi: 10.1111/j.1525-1594.1981.tb04019.x.
8
Factors predictive of acute renal failure in rhabdomyolysis.横纹肌溶解症中急性肾衰竭的预测因素。
Arch Intern Med. 1988 Jul;148(7):1553-7.
9
Plasma exchange after revascularization compartment syndrome with acute toxic nephropathy caused by rhabdomyolysis.
J Vasc Surg. 1988 Jun;7(6):757-8. doi: 10.1067/mva.1988.avs0070757.
10
Plasma exchange in rhabdomyolysis.横纹肌溶解症中的血浆置换
Intensive Care Med. 1989;15(8):528-9. doi: 10.1007/BF00273565.
Zotero 插件