Kuroda M, Katsuki K, Uehara H, Kita T, Asaka S, Miyazaki R, Akiyama T, Tofuku Y, Takeda R
Artif Organs. 1981 Nov;5(4):372-8. doi: 10.1111/j.1525-1594.1981.tb04019.x.
The first successful treatment by plasma exchange of acute renal failure and disseminated intravascular coagulation, as well as liver and central nervous system damage, was achieved in two patients with severe multiorgan damage associated with extensive muscle tissue damage caused by heatstroke and/or electrical injury. Substances derived from damaged muscle tissue, such as myoglobin and enzymes, were efficiently removed by a cellulose acetate membrane filter. Improvement of consciousness, disturbance, coagulation disorder, and renal failure were observed. The disorders associated with extensive rhabdomyolysis seem to be a promising indication for this therapy. Plasma exchange with a membrane filter is useful for treatment of patients with renal failure, being readily connected on-line with conventional dialysis.
两名因中暑和/或电击伤导致广泛肌肉组织损伤并伴有严重多器官损伤的患者，通过血浆置换首次成功治疗了急性肾衰竭、弥散性血管内凝血以及肝脏和中枢神经系统损伤。受损肌肉组织衍生的物质，如肌红蛋白和酶，通过醋酸纤维素膜过滤器被有效清除。观察到意识、精神障碍、凝血障碍和肾衰竭有所改善。与广泛横纹肌溶解相关的病症似乎是这种治疗方法的一个有前景的适应症。使用膜过滤器进行血浆置换对肾衰竭患者的治疗很有用，它很容易与传统透析在线连接。
